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Pip3.0

Piperlongumine

Limited safety

Evidence

Evidence Score3/10

Studies: 18

Meta-analyses: 0

Dosage & timing

Dosage:

No validated human dose exists. All dosing is preclinical (cell-culture micromolar concentrations or mg/kg in mice). Piperlongumine is a research chemical with poor oral bioavailability — there is no established or safe human regimen, and it is not appropriate for self-administration.

Best Time:

Any time

Can take on empty stomach

Form:

None established (preclinical research compound)

What you'll notice

🧹 Senescent-cell clearance (in-vitro)positive

Unknown in humans

🔬 Selective cancer-cell killing (animal)positive

Unknown in humans

ℹ️ No human efficacy dataneutral

N/A

Safety

Limited safety

Contraindications:

Any non-research human use
Pregnancy / breastfeeding
Concurrent chemotherapy or other cytotoxic agents (research interactions only)

Drug Interactions:

Antioxidants (e.g. N-acetylcysteine)
Chemotherapy (e.g. cisplatin)

Side Effects:

Pro-oxidant / genotoxic cytotoxicity

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