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Pha4.0

Polyhydroxy Acids (PHA)

High safety

Evidence

Evidence Score4/10

Studies: 6

Meta-analyses: 0

Dosage & timing

Dosage:

Topical cosmetic only. PHAs (gluconolactone, lactobionic acid) are used in leave-on toners, serums, and creams applied to clean skin, typically building from a few times weekly to daily as tolerated; sunscreen is recommended. There is no oral or systemic dose — they are not ingested. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on PHA toner, serum, or cream (gluconolactone or lactobionic acid)

What you'll notice

ℹ️ The gentle exfoliating acid — cosmetic onlyneutral

Throughout

💆 Comparable anti-aging, much gentlerpositive

8-12 weeks

✅ Suited to sensitive/rosacea-prone skinpositive

Throughout

Safety

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to the formulation
Active dermatitis or broken/sunburned skin until healed

Drug Interactions:

Other leave-on actives (retinoids, AHAs/BHAs)

Side Effects:

Mild stinging or dryness

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