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Prescription-only and clinician-directed — this is a hormonal prescription drug, not a self-administered supplement, and dosing is indication-specific. For context only: for endometrial protection in menopausal hormone therapy, oral micronized progesterone is commonly ~100 mg daily (continuous-combined) or ~200 mg for ~12 days a month (sequential), taken at bedtime. For IVF luteal support, vaginal progesterone is typically used (e.g. ~90–200 mg twice or three times daily) under a fertility clinic. Doses for sleep/vasomotor use in trials were ~300 mg at bedtime. Oral micronized progesterone is dosed at night because it is sedating and because first-pass metabolism gives it low oral bioavailability.

Before bed · with food

Clinician-prescribed oral micronized progesterone (Prometrium / Utrogestan) at bedtime for HRT endometrial protection and menopausal sleep/vasomotor use — prescription-only

• Use without a prescription / without medical supervision — progesterone is a prescription hormonal drug, not a dietary supplement
• Known or suspected breast cancer or other progesterone-sensitive cancer (per product labeling)
• Active or history of venous thromboembolism, arterial thromboembolic disease, or known thrombophilia (combined HRT context)

• CNS depressants (alcohol, benzodiazepines, sedatives, opioids)
• CYP3A4 inducers (rifampicin, carbamazepine, phenytoin, St John's wort)
• Estrogen (in combined HRT)