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PT-141

Evidence Score5/10

Studies: 25

Meta-analyses: 2

Dosage:

Approved (Vyleesi): 1.75 mg subcutaneous, self-injected on-demand ~45 min before anticipated sexual activity; max 1 dose/24 h and 8 doses/month

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous auto-injector (Vyleesi)

💞 Increased sexual desire / reduced distress (HSDD)positive

On-demand (per dose); endpoints assessed over 24 weeks

📏 Small clinical effect sizeneutral

Throughout

🤢 Nauseatrade-off

Within hours of dosing

Limited safety

Contraindications:

Uncontrolled hypertension or known cardiovascular disease (transient BP increase)
Pregnancy and breastfeeding
Not a dietary supplement — prescription-only; do not self-source grey-market vials

Drug Interactions:

Side Effects:

NauseaFlushingHeadache

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