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Tdl3.0

Tadalafil

Limited safety

Evidence

Evidence Score3/10

Studies: 5

Meta-analyses: 0

Dosage & timing

Dosage:

Off-label longevity/vascular use mirrors low approved dosing (e.g. tadalafil 2.5–5 mg once daily, the dose used for BPH/daily ED) under a clinician. Not an approved longevity regimen.

Best Time:

Any time

Can take on empty stomach

Form:

Low daily-dose oral tablet

What you'll notice

📊 Lower mortality (associational)positive

Years

🧠 Possible lower dementia riskpositive

Years

🩸 Endothelial / vascular benefitpositive

Acute to weeks

Safety

Limited safety

Contraindications:

Concurrent nitrates (any form)
Recent cardiovascular event / unstable angina
Severe hypotension

Drug Interactions:

Nitrates
Alpha-blockers / antihypertensives
Strong CYP3A4 inhibitors

Side Effects:

Headache / flushingNasal congestion / indigestion / back painHypotension / priapism / sudden vision or hearing changes

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