Compare Supplements

Side-by-side comparison of 2 supplements

Tir7.8

Tirzepatide

Limited safety

B127.5

Vitamin B12

High safety

Evidence

Evidence Score7.8/10

Studies: 13

Meta-analyses: 2

Evidence Score7.5/10

Studies: 79

Meta-analyses: 20

Dosage & timing

Dosage:

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

Dosage:

500-1000mcg daily for maintenance; higher for deficiency

Best Time:

Morning · with food (preferred)

Can take on empty stomach

Form:

Methylcobalamin (sublingual)

What you'll notice

🩸 Strong glycemic controlpositive

Weeks to months

⚖️ Large weight losspositive

Months (dose-escalated over ~20 weeks)

😴 Reduced sleep-apnea severitypositive

Weeks to months

⚡ Energy Restorationpositive

2-4 weeks

🧠 Cognitive Supportpositive

4-8 weeks

⚡ Nerve Healthpositive

Weeks to months

Safety

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple endocrine neoplasia syndrome type 2 (MEN2)
History of pancreatitis (use with caution / avoid)

Drug Interactions:

Oral contraceptives
Insulin and sulfonylureas
Oral medications generally

Side Effects:

NauseaDiarrheaVomiting

High safety

Contraindications:

Leber's hereditary optic neuropathy (may worsen)
Cobalt or cobalamin hypersensitivity

Drug Interactions:

Metformin
PPIs (proton pump inhibitors)

Side Effects:

Mild GI upsetAcne-like skin eruption (high doses)Allergic reaction (rare, usually with injection)

Works well with

No synergies listed

Methylfolate

complementary

L-Methionine

enhances

Pantothenic Acid

complementary

How they work together

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