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Ver4.6

Verapamil

Limited safety

Evidence

Evidence Score4.6/10

Studies: 7

Meta-analyses: 1

Dosage & timing

Dosage:

Off-label beta-cell use in new-onset T1D mirrors trial dosing (the adult Ver-A-T1D trial used roughly weight-based ~120–360 mg/day of extended-release verapamil) added to a standard insulin regimen, under a clinician — ideally within a trial framework. A prescription drug; not an approved or standardized regimen for T1D.

Best Time:

With meals · with food

Take with food

Form:

Extended-release tablet

What you'll notice

🧬 Preserves beta-cell C-peptide (new-onset T1D)positive

3–12 months

💉 Lower insulin needs / fewer hypospositive

Months

❤️ Approved cardiovascular effectspositive

Hours to weeks

Safety

Limited safety

Contraindications:

Significant left-ventricular dysfunction / decompensated heart failure
Severe bradycardia, sick-sinus syndrome, or second/third-degree AV block (without a pacemaker)
Severe hypotension or cardiogenic shock

Drug Interactions:

Beta-blockers
Digoxin
CYP3A4 substrates / statins (e.g. simvastatin)

Side Effects:

ConstipationBradycardia / hypotension / dizzinessAV block

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