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Vitamin B12

9/10high

Evidence

Evidence Score9/10

Studies: 40+

Meta-analyses: 21

Dosage & Timing

Dosage:

500-1000mcg daily for maintenance; higher for deficiency

Best Time:

Morning (may be energizing), With or without food

Can take on empty stomach

Form:

Methylcobalamin (sublingual)

What You'll Notice

⚡ Energy Restoration80%

2-4 weeks

🧠 Cognitive Support65%

4-8 weeks

⚡ Nerve Health70%

Weeks to months

Safety

high safety rating

Contraindications:

Leber's hereditary optic neuropathy (may worsen)
Cobalt or cobalamin hypersensitivity

Drug Interactions:

Metformin
PPIs (proton pump inhibitors)

Side Effects:

Mild GI upsetAcne-like skin eruption (high doses)Allergic reaction (rare, usually with injection)

Works Well With

Methylfolatecomplementary

L-Methionineenhances

Pantothenic Acidcomplementary

Compare Supplements

Vitamin B12

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

Compare Supplements

Vitamin B12

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories