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Aln4.0

Allantoin (topical) Research

Mostly mechanism / observational

7 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Allantoin (topical) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 2012–2020 with a typical study size of 50 participants.

Based on 7 studies · 5 RCTs · 206 total participants

Confidence

Moderate confidence

By outcome

Wound & ulcer healing
Mostly mechanism / observational3 studies

Older research base

Newest study from 2020

20122020

1RCT2014

Chan RJ, Mann J, Tripcony L, Keller J, Cheuk R, Blades R · Int J Radiat Oncol Biol Phys (2014)

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2RCT2012

Chan RJ, Keller J, Cheuk R, Blades R, Tripcony L, Keogh S · Radiat Oncol (2012)

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3Systematic Review2017

In plain English: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.

Ferreira EB, Vasques CI, Gadia R, Chan RJ, Guerra EN, Mezzomo LA, De Luca Canto G, Dos Reis PE. · Support Care Cancer (2017)

Systematic review of 13 RCTs of topical agents (including allantoin, trolamine, dexpanthenol, aloe vera) for preventing radiation dermatitis
Found no strong evidence that any topical pharmacological intervention, allantoin included, outperformed controls or placebo
Tempers claims of a robust soothing/protective benefit for topical allantoin in inflamed skin — the key counter-evidence

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4RCTn=50 · small study2016

In plain English: The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients' postoperative comfort; however, improved wound healing was observed.

Madrazo-Jiménez M, Rodríguez-Caballero Á, Serrera-Figallo MÁ, Garrido-Serrano R, Gutiérrez-Corrales A, Gutiérrez-Pérez JL, Torres-Lagares D. · Med Oral Patol Oral Cir Bucal (2016)

Split-mouth randomized trial (n=50 extractions): allantoin-containing gel applied 3x/day for 10 days vs no gel
Wound aesthetic appearance was significantly better in the gel group at day 7 (p=0.001) and day 14 (p=0.01)
No significant difference in swelling or pain; allantoin's individual contribution can't be separated from the other actives

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5RCTn=36 · small study2020

In plain English: The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation.

Sáez-Alcaide LM, Molinero-Mourelle P, González-Serrano J, Rubio-Alonso L, Bornstein MM, López-Quiles J. · Med Oral Patol Oral Cir Bucal (2020)

Split-mouth, double-blind, placebo-controlled RCT (n=36, 72 teeth); gel contained 0.15% allantoin with chlorhexidine, chitosan, and dexpanthenol
Trismus and swelling were significantly less with the gel; wound healing was 'good' in 97.2% vs 22.2% for placebo (p<0.001)
Soothing/anti-inflammatory benefit attaches to the multi-ingredient formulation, not isolated allantoin

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6RCTn=120 · medium study2020

In plain English: Significant reductions were observed in the vascularity, pigmentation and height subgroups of the VSS for those in the group who continued the treatment to 24 weeks.

Güngör ES, Güzel D, Zebitay AG, İlhan G, Verit FF. · J Wound Care (2020)

Randomized study (n=120) of an onion-extract + allantoin + heparin gel for 6 months vs no treatment on hypertrophic C-section scars
Treatment significantly reduced Vancouver Scar Scale vascularity, pigmentation, and height at 24 weeks
A fixed combination product — allantoin is not tested alone; benefit is modest and formulation-level

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7In Vitro2018

In plain English: An in vitro scratch assay confirmed the healing activity of tracheloside (more than 2-fold increased healing activity after 24 hours of treatment compared with the control) and revealed that this activity is better than that of allantoin (1.2-fold increased after 24 hours of treatment compared with the control), a positive control.

Kim J, Shin YK, Kim KY. · Evid Based Complement Alternat Med (2018)

In-vitro HaCaT keratinocyte scratch-wound assay using allantoin as the established positive control for wound-healing activity
Allantoin produced a measurable but modest 1.2-fold increase in healing activity vs control at 24 hours
Supports a plausible cell-proliferation mechanism, but the small effect underscores allantoin's modest intrinsic potency

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View in Research Library

Allantoin (topical) Research

Mostly mechanism / observational

Natural oil-based emulsion containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer: a phase 3, double-blind, randomized, controlled trial.

A double-blind randomised controlled trial of a natural oil-based emulsion (Moogoo Udder Cream®) containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer.

Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review.

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction.

Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial.

The efficacy of onion extract in the management of subsequent abdominal hypertrophic scar formation.

Promotion of Keratinocyte Proliferation by Tracheloside through ERK1/2 Stimulation.