Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren
Ar7.5
Arginin – Forschung
Hilft vermutlich
381 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Arginin half in etwa der Hälfte (12/20) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1979–2026 mit einer typischen Studiengröße von 203 Teilnehmenden.
Basierend auf 379 Studien · 42 Meta-Analysen · 314 RCTs · 25,884 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
12geholfen6unklar2nicht geholfen· 359 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureVerbessert Endothelfunktion und Blutdruck über Stickstoffmonoxid · 4-8 Wochen
Hilft wahrscheinlich91 Studien
Therapeutic & clinical
Hilft wahrscheinlich46 Studien
Women's health
Hilft wahrscheinlich31 Studien
Wound & ulcer healing
Hilft vermutlich19 Studien
Endurance & exercise performanceVerbesserte Durchblutung und Sauerstoffversorgung · 1-2 Wochen · NO-Vorstufe; moderate Verbesserungen der Belastungstoleranz · 30-60 Minuten
Überwiegend Mechanismus / Beobachtung14 Studien
Men's vitality
Überwiegend Mechanismus / Beobachtung12 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung12 Studien
InflammationBessere Endothelfunktion und Blutdruck · 2-4 Wochen
Cholesterol & lipidsVerbessert Endothelfunktion und Blutdruck über Stickstoffmonoxid · 4-8 Wochen
Zu wenige bewertete Studien2 Studien
Neuroprotection & brain aging
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 34 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
78%
über Studien hinweg
Untersuchte Personen
26k
typische Studie: 203 Personen
Stärkste Designs
356
42 gepoolt, 314 randomisiert
Zeigte Nutzen
55%
11/20 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
1
Untersuchte Populationen
Men with erectile dysfunction3
Pregnant women2
Adults2
Men with mild to moderate erectile dysfunction2
Stetige Forschung
69 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
197920022026
1Pre-eclampsia riskMeta-Analysen=2,028 · very large study2025
Einfach gesagt: L-arginine may be promising for pre-eclampsia prevention and treatment, but findings should be interpreted cautiously.
Makama M et al. · BJOG : an international journal of obstetrics and gynaecology (2025)
Groß Nutzen
← SchlechterKein EffektBesser →
In prevention trials, L-arginine was associated with a reduced risk of pre-eclampsia (relative risk [RR] 0.52; 95% confidence interval [CI], 0.35, 0.78; low-certainty evidence, four trials) and severe pre-eclampsia (RR 0.23; 95% CI, 0.09, 0.55; low-certainty evidence, three trials).
In treatment trials, L-arginine may reduce mean systolic blood pressure (MD -5.64 mmHg; 95% CI, -10.66, -0.62; very low-certainty evidence, three trials) and fetal growth restriction (RR 0.46; 95% CI, 0.26, 0.81; low-certainty evidence, two trials).
L-arginine may be promising for pre-eclampsia prevention and treatment, but findings should be interpreted cautiously.
2Total postoperative complicationsMeta-Analysen=4,825 · very large study2024
Einfach gesagt: Nutritional intervention with perioperative immunonutrition in patients with HAN and GI cancers significantly reduced total postoperative complications and infectious complications.
Matsui R et al. · Annals of surgery (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Immunonutrition reduced the total postoperative complications (relative risk ratio: 0.78; 95% CI, 0.66-0.93; certainty of evidence: high) and infectious complications (relative risk ratio: 0.71; 95% CI, 0.61-0.82; certainty of evidence: high) compared with standard nutritional therapy.
3Pressure ulcer incidenceMeta-Analysen=7,920 · very large study2024
Einfach gesagt: The benefits of nutritional interventions with various compositions for pressure ulcer prevention and treatment are uncertain.
Langer G et al. · The Cochrane database of systematic reviews (2024)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Compared to standard diet, protein supplements may result in little to no difference in pressure ulcer incidence (protein 21 per 1000, standard diet 28 per 1000; RR 0.75, 95% CI 0.49 to 1.14; 4 studies, 4264 participants; low-certainty evidence).
The evidence is very uncertain about the gastrointestinal side effects of these supplements (protein 109 per 1000, standard diet 155 per 1000; RR 0.70, 95% CI 0.06 to 7.96; 2 studies, 140 participants, very low-certainty evidence).
Compared to standard diet, energy, protein and micronutrient supplements may slightly increase the number of healed pressure ulcers (energy, protein and micronutrients 366 per 1000, standard diet 253 per 1000; RR 1.45, 95% CI 1.14 to 1.85; 3 studies, 577 participants, low-certainty evidence).
4Erectile function improvementMeta-Analysen=1,000 · large study2024
Einfach gesagt: Against a background of general ineffectiveness of most nutraceutical interventions, L-Arginine and the mix PLC + ALC appeared to be of some usefulness in improving erectile function, especially in combination with PDE5i in organic ED.
Barbonetti A et al. · The journal of sexual medicine (2024)
In patients with organic ED, the efficacy of Sildenafil and Tadalafil was significantly improved by PLC + ALC and L-Arginine, respectively.
Against a background of general ineffectiveness of most nutraceutical interventions, L-Arginine and the mix PLC + ALC appeared to be of some usefulness in improving erectile function, especially in combination with PDE5i in organic ED.
5Tumor necrosis factor-α reductionMeta-Analysen=2,841 · very large study2023
Einfach gesagt: Future well-designed RCTs are needed to further confirm these findings.
Ye J et al. · Nutrients (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Glutamine was superior in decreasing tumor necrosis factor-α (MD -25.2; 95% CrI [-32.62, -17.95]), whereas combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85]).
No nutritional supplements significantly maintained nutritional indicators in CRC patients.
Future well-designed RCTs are needed to further confirm these findings.
Einfach gesagt: The pooled analysis demonstrated significant decreases in SBP (WMD = -6.40 mmHg; 95% CI: -8.74, -4.05; P < 0.001) and DBP (WMD = -2.64 mmHg; 95% CI: -3.94, -1.40; P < 0.001) after l-arginine supplementation.
Shiraseb F et al. · Advances in Nutrition (2022)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Twenty-two RCTs with 30 effect sizes were included in this meta-analysis.
The pooled analysis demonstrated significant decreases in SBP (WMD = -6.40 mmHg; 95% CI: -8.74, -4.05; P < 0.001) and DBP (WMD = -2.64 mmHg; 95% CI: -3.94, -1.40; P < 0.001) after l-arginine supplementation.
Subgroup analysis showed significant reductions in SBP and DBP regardless of baseline BP category, study duration, sex, health status, and BMI.
8Sexual function improvementMeta-Analysen=373 · medium study2021
Einfach gesagt: Besides, PDE5Is alone revealed a better effect than those treated with L-arginine alone for patients with ED.
Xu Z et al. · Andrologia (2021)
Erectile functions were significantly improved in three therapy groups compared with baseline.
Conclusively, compared with monotherapy, the combination of L-arginine and PDE5Is showed a greater improvement of sexual function and total testosterone, and did not significantly increase the AEs.
Furthermore, patients who treated with PDE5Is alone exhibited the better efficacy than those treated with L-arginine alone in respects of sexual function index (p <0.00001) and total testosterone (p =0.0001).
9Erectile dysfunction improvementMeta-Analysen=540 · large study2019
Einfach gesagt: The results of our systematic review and meta-analysis provide evidence on the effectiveness of arginine supplements for mild to moderate ED.
Rhim HC et al. · The journal of sexual medicine (2019)
Sehr groß Schaden
← SchlechterKein EffektBesser →
Likely real
The analysis demonstrated that arginine supplements with dosage ranging from 1,500 to 5,000 mg significantly improved ED compared with placebo or no treatment (odds ratios, 3.37 [1.29, 8.77], P = .01, I2 = 44).
Arginine supplements also caused significant improvements in the IIEF subdomain scores of overall satisfaction, intercourse satisfaction, orgasmic function, and erectile function, whereas the IIEF sexual desire score remain unchanged.
The adverse effect rate in the arginine-treated group was 8.3%, and that in the placebo group was 2.3%, none of which were severe.
15Sexual function in erectile dysfunctionMeta-Analysen=184 · medium study2023
Einfach gesagt: These results indicate that the combination of PAL may have a significant effect on improving sexual function in patients with mild to moderate ED.
Tian Y et al. · Frontiers in endocrinology (2023)
These results indicate that the combination of PAL may have a significant effect on improving sexual function in patients with mild to moderate ED.
This study will provide clinicians with more options for treating patients with ED.
More randomized controlled trials are needed in the future to further demonstrate the effect of combination therapy on sexual function in patients with ED.
16Proportion of ulcers healedMeta-Analysen=629 · large study2020
Einfach gesagt: Evidence for the impact of nutritional interventions on the healing of foot ulcers in people with diabetes compared with no nutritional supplementation, or compared with a different dose of nutritional supplementation, remains uncertain, with eight studies showing no clear benefit or harm.
Moore ZE et al. · The Cochrane database of systematic reviews (2020)
Kein klarer Effekt
← SchlechterKein EffektBesser →
It is also uncertain whether arginine, glutamine and β-hydroxy-β-methylbutyrate supplement increases the proportion of ulcers healed at 16 weeks compared with placebo (RR 1.09, 95% CI 0.85 to 1.40).
It is uncertain whether oral nutritional supplement with 20 g protein per 200 mL bottle, 1 kcal/mL, nutritional supplement with added vitamins, minerals and trace elements, reduces the number of deaths (RR 0.96, 95% CI 0.06 to 14.60) or amputations (RR 4.82, 95% CI 0.24 to 95.88) more than placebo.
It is uncertain whether arginine, glutamine and β-hydroxy-β-methylbutyrate supplement increases health-related quality of life at 16 weeks more than placebo (MD -0.03, 95% CI -0.09 to 0.03).