42 peer-reviewed studies · Evidence score: 7.5/10
Weiner JD et al. • Lupus science & medicine (2025)
We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
Sherafati N et al. • Complementary therapies in medicine (2022)
We found that Chlorella vulgaris supplementation had a beneficial effect on TC and LDL-C levels with no significant effect on TG and HDL-C levels.
Furulund E et al. • International journal of chronic obstructive pulmonary disease (2021)
Increasing intake of fruits and vegetables over prolonged periods might have positive effects on lung function in individuals with COPD.
Fallah AA et al. • Clinical nutrition (Edinburgh, Scotland) (2018)
The results indicated that Chlorella supplementation improved levels of TC, LDL-C, SBP, DBP, and FBG but the changes in TG, HDL-C, and BMI were not satisfactory.
Lacurezeanu A et al. • Molecular nutrition & food research (2025)
Molecular Nutrition & Food Research
Kazeminejad S et al. • Nutrition reviews (2025)
Overall, the findings of this meta-analysis indicate supplementation with algae may exert beneficial effects on anthropometric indices.
Fallah AA et al. • Complementary Therapies in Medicine (2018)
Chlorella supplementation significantly reduced total cholesterol, LDL-C, fasting blood glucose, and body weight.
Pinto-Leite M et al. • Nutrients (2025)
Conclusions: Further randomised trials are needed to better assess the potential of these supplements as adjuvants for the control of cardiovascular risk factors.
Lowry E et al. • Nutrients (2020)
Therefore, there is insufficient evidence to recommend any one particular nutritional intervention for the management of fibromyalgia and further research is needed.
Wang Z et al. • Nutrients (2026)
Consequently, while the evidence suggests the possibility of functional effects, the strength of the evidence and its generalizability across populations remains limited.
Chiu HF et al. • Journal of food biochemistry (2021)
However, large-scale clinical studies are needed to confirm our statements.
Kim S et al. • Nutrition journal (2016)
The results suggest that a fully replicated dietary cholesterol challenge may be useful in assessing the effectiveness of dietary supplements in maintaining the serum lipid profiles of adults whose habitual diets are high in cholesterol.
White H et al. • Nutrients (2024)
A total of 2 days of 6 g/day chlorella supplementation appears to lower the blood lactate response and increase O2 pulse during both submaximal and maximal intensity exercise but did not lead to any improvements in V˙O2max.
Sandgruber F et al. • Nutrients (2023)
An elevated uric acid concentration in blood and urine following the regular consumption of microalgae poses potential risks for human health.
van der Heijden I et al. • The British journal of nutrition (2024)
The ingestion of a variety of novel non-animal-derived dietary protein sources elicits divergent plasma amino acid responses, which are further modulated by age.
Gurney T et al. • Journal of dietary supplements (2024)
In conclusion, chlorella may pose as an additional supplement for cyclists to consider, particularly for those cyclists who want to improve their sprinting.
Hosseini AM et al. • European journal of nutrition (2021)
According to the findings of this study, supplementation with C. vulgaris with a dosage of 1500 mg/day for 8 weeks, does not improve the anthropometric measurements, glycemic status, and lipid profile as well.
Ebrahimi-Mameghani M et al. • Clinical nutrition (Edinburgh, Scotland) (2017)
To our finding, C. vulgaris supplementation could be considered as an adjunctive therapy to decrease weight and improve glycemic status and reducing hs-CRP as well as improving liver function in patients with NAFLD.
Ryu NH et al. • Nutrition journal (2014)
Daily consumption of Chlorella supplements provided the potential of health benefits reducing serum lipid risk factors, mainly triglycerides and total cholesterol, in mildly hypercholesterolemic subjects.
Kwak JH et al. • Nutrition journal (2012)
These results may suggest a beneficial immunostimulatory effect of short-term Chlorella supplementation which enhances the NK cell activity and produces interferon-γ and interleukin-12 as well as interleukin-1β, the Th-1 cell-induced cytokines in healthy people.