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Coq8.0
CoQ10 Research
Likely helps
328 peer-reviewed studies
What the evidence says
Likely helps
CoQ10 appears to help in 16 of 20 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 1993–2026 with a typical study size of 326 participants.
Based on 328 studies · 74 meta-analyses · 224 RCTs · 38,466 total participants
Confidence
High confidence
What the studies found
16helped1unclear3didn't help· 308 more without graded effect data
By outcome
Therapeutic & clinical
Mostly mechanism / observational51 studies
Heart & blood pressureImproved cardiac energy production and blood pressure within 4-8 weeks · 4-8 weeks
Mostly mechanism / observational33 studies
Glucose & metabolicSupports mitochondrial ATP production and metabolic efficiency · 8-12 weeks
Mostly mechanism / observational22 studies
Energy & fatigueReduced fatigue, especially if depleted · 2-4 weeks
Mostly mechanism / observational21 studies
Fertility & reproductiveMay support reproductive health and fertility markers · 4-12 weeks
Probably helps17 studies
Cholesterol & lipidsImproved cardiac energy production and blood pressure within 4-8 weeks · 4-8 weeks
Mostly mechanism / observational16 studies
InflammationReduces CRP and IL-6 inflammatory markers in meta-analyses · 4-8 weeks
Mostly mechanism / observational13 studies
Migraine & headache
Mostly mechanism / observational11 studies
Endurance & exercise performanceSupports mitochondrial ATP for endurance output · 4-8 weeks
Mostly mechanism / observational6 studies
Neuroprotection & brain agingSupports neuronal mitochondrial energy · 8-12 weeks
Mostly mechanism / observational5 studies
Skin healthReduced wrinkles in a small RCT of oral CoQ10 · 12 weeks · Modest improvement in skin smoothness/elasticity · 12 weeks
Mostly mechanism / observational5 studies
Safety profile
Mostly mechanism / observational5 studies
Vision & eye health
Too few graded studies2 studies
By the numbers
Pulled from 57 studies with measurable effects
Likely real effects
92%
across studies
People studied
38k
typical study: 326 people
Strongest designs
298
74 pooled, 224 randomised
Showed benefit
80%
16/20 studies
How long studies ran
1–3 months
2
3+ months
4
Populations Studied
Heart failure patients3
Women with polycystic ovary syndrome1
Women with ovarian aging1
Women with diminished ovarian reserve1
Steady research
97 studies in the last 5 years · Latest meta-analysis: 2026
199320092026
1Meta-Analysisn=574 · large study2026
In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment.
Lyons S et al. · The Cochrane database of systematic reviews (2026)
Meta-analysis of seven studies demonstrated that pharmacological treatment probably makes little or no difference to scores on the ataxia rating scale after 12 months of treatment (SMD 0.02, 95% CI -0.23 to 0.26; I² = 42%; 7 studies, 513 participants; moderate-certainty evidence).
The evidence was very uncertain about the effects of treatment on IVSTd (MD -0.51, 95% CI -1.10 to 0.09; I² = 80%; 2 studies, 72 participants; very low-certainty evidence) and on ADL (MD -0.59, 95% CI -1.39 to 0.21; I² = 24%; 3 studies, 167 participants; very low-certainty evidence).
Meta-analysis of three studies showed that treatment probably improves upper limb dexterity (SMD -0.42, 95% CI -0.73 to -0.11; I² = 0%; 3 studies, 166 participants; moderate-certainty evidence).
3Clinical pregnancy ratesMeta-AnalysisCited 25×n=2,617 · very large study2024
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to...
Shang Y et al. · Advances in nutrition (Bethesda, Md.) (2024)
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates.
Appropriate antioxidant treatment should be offered at a low dose according to the patient's age and ovarian reserve.
This study was registered at PROSPERO as CRD42022359529.
5Inflammatory mediatorsMeta-AnalysisCited 13×n=1,517 · large study2023
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
Hou S et al. · Molecular nutrition & food research (2023)
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
6Clinical pregnancy rateMeta-AnalysisCited 11×n=2,323 · very large study2023
Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
Zhu F et al. · Reproductive biology and endocrinology : RB&E (2023)
Huge harm
← WorseNo effectBetter →
Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
CoQ10 was the best in improving the live birth rate (OR 2.36, 95% CI: 1.07 to 5.38).
DHEA increased the embryo implantation rate (OR 2.80, 95%CI: 1.41 to 5.57) and the high-quality embryo rate (OR 2.01, 95% CI: 1.07 to 3.78) and number of oocytes retrieved (WMD 1.63, 95% CI: 0.34 to 2.92) showed a greater advantage, with GH in second place.
7All-cause mortalityMeta-AnalysisCited 53×n=1,573 · large study2021
The included studies provide moderate-quality evidence that coenzyme Q10 probably reduces all-cause mortality and hospitalisation for heart failure.
Al Saadi T et al. · The Cochrane database of systematic reviews (2021)
Large benefit
← WorseNo effectBetter →
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
There was low-quality evidence of inconclusive results between the coenzyme Q10 and control groups for the risk of myocardial infarction (RR 1.62, 95% CI 0.27 to 9.59; 1 study, 420 participants), and stroke (RR 0.18, 95% CI 0.02 to 1.48; 1 study, 420 participants).
Coenzyme Q10 probably reduces hospitalisation related to heart failure (RR 0.62, 95% CI 0.49 to 0.78; 2 studies, 1061 participants; NNTB 9.7; moderate-quality evidence).
8Lipid profile improvementMeta-AnalysisCited 22×n=2,794 · very large study2022
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
Liu Z et al. · The Journal of clinical endocrinology and metabolism (2022)
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
9Clinical pregnancy rateMeta-AnalysisCited 64×n=6,510 · very large study2017
In this review, there was very low-quality evidence to show that taking an antioxidant may provide benefit for subfertile women, but insufficient evidence to draw any conclusions about adverse events.
Showell MG et al. · The Cochrane database of systematic reviews (2017)
This suggests that among subfertile women with an expected clinical pregnancy rate of 22%, the rate among women using antioxidants would be between 27% and 33%.
Heterogeneity was moderately high.There was insufficient evidence to determine whether there was a difference between the groups in rates of miscarriage (OR 0.79, 95% CI 0.58 to 1.08, P = 0.14, 18 RCTs, 2834 women, I2 = 23%, very low quality evidence).
This suggests that, among subfertile women with an expected miscarriage rate of 7%, use of antioxidants would be expected to result in a miscarriage rate of between 4% and 7%.