67 peer-reviewed studies · Evidence score: 9/10
Hu X et al. • PeerJ (2023)
Carnitine was relatively effective in reducing body mass, while chromium, Omega-3, and selenium were beneficial for improving glucose metabolism.
Zhang T et al. • Reproductive sciences (Thousand Oaks, Calif.) (2023)
The Author(s), under exclusive licence to Society for Reproductive Investigation.
Shang Y et al. • Advances in nutrition (Bethesda, Md.) (2024)
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to...
Lin G et al. • Annals of medicine (2024)
These findings suggested that CoQ10 pretreatment is an effective intervention in improving IVF/ICSI outcomes for women with DOR.
Hou S et al. • Molecular nutrition & food research (2023)
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
Zhu F et al. • Reproductive biology and endocrinology : RB&E (2023)
Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
Al Saadi T et al. • The Cochrane database of systematic reviews (2021)
The included studies provide moderate-quality evidence that coenzyme Q10 probably reduces all-cause mortality and hospitalisation for heart failure.
Liu Z et al. • The Journal of clinical endocrinology and metabolism (2022)
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
Showell MG et al. • The Cochrane database of systematic reviews (2017)
In this review, there was very low-quality evidence to show that taking an antioxidant may provide benefit for subfertile women, but insufficient evidence to draw any conclusions about adverse events.
Zhang Y et al. • Human reproduction update (2020)
Furthermore, high-level RCT studies using uniform standards for POR need to be incorporated into future meta-analyses.
Daei S et al. • High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension (2024)
CoQ10 supplementation has a positive effect on FMD in a dose-dependent manner.
Talandashti MK et al. • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2025)
The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis.
Michaelsen MP et al. • Nutrients (2025)
This study found no convincing evidence of an effect of any dietary supplements on male infertility.
Gabriel FC et al. • Nutritional neuroscience (2023)
The 27 interventional studies mainly focused on fatty acids, micronutrients and N-acetylcysteine (NAC).
Sazali S et al. • BMJ open (2021)
CoQ10 appears to have beneficial effects in reducing duration and frequency of migraine attack.
Qu H et al. • Journal of the American Heart Association (2018)
Conclusions CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy.
Xu J et al. • BMC cardiovascular disorders (2024)
According to the existing evidence, coenzyme Q10 reduces all-cause mortality, hospitalization for heart failure, New York Heart Association classification, and brain natriuretic peptide level and improves left ventricular ejection fraction and 6-min walk test result in those with heart failure without major adverse effects.
Drovandi S et al. • Kidney international (2022)
Isolated kidney involvement at diagnosis occurred in 34% of COQ2, 10.8% of COQ6 and 70.7% of COQ8B variant individuals.
Moradi M et al. • Complementary Therapies in Medicine (2019)
CoQ10 supplementation significantly reduced fasting blood glucose, HbA1c, and triglycerides in type 2 diabetic patients.
Parohan M et al. • Nutritional neuroscience (2020)
Conclusion: Pooled analyses of available randomized clinical trials suggest that Coenzyme Q10 supplementation may reduce the frequency of migraine attacks per month without affecting the severity or duration of migraine attacks.