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Coq9.0
CoQ10 Research
Likely helpsHigh safety
63 peer-reviewed studies
What the evidence says
Likely helps
CoQ10 appears to help in 16 of 20 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2007–2026 with a typical study size of 326 participants.
Based on 63 studies · 33 meta-analyses · 17 RCTs · 34,834 total participants
Confidence
High
What the studies found
16helped1unclear3didn't help· 43 more without graded effect data
By outcome
Fertility & reproductiveMay support reproductive health and fertility markers · 4-12 weeks
Probably helps14 studies
Therapeutic & clinical
Mostly mechanism / observational10 studies
Heart & blood pressureImproved cardiac energy production and blood pressure within 4-8 weeks · 4-8 weeks
Mostly mechanism / observational6 studies
Glucose & metabolicSupports mitochondrial ATP production and metabolic efficiency · 8-12 weeks
Mostly mechanism / observational5 studies
Safety profile
Mostly mechanism / observational5 studies
Cholesterol & lipidsImproved cardiac energy production and blood pressure within 4-8 weeks · 4-8 weeks
Mostly mechanism / observational4 studies
Migraine & headache
Mostly mechanism / observational4 studies
Energy & fatigueReduced fatigue, especially if depleted · 2-4 weeks
Mostly mechanism / observational3 studies
Endurance & exercise performanceSupports mitochondrial ATP for endurance output · 4-8 weeks
Too few graded studies2 studies
Neuroprotection & brain agingSupports neuronal mitochondrial energy · 8-12 weeks
Too few graded studies2 studies
InflammationReduces CRP and IL-6 inflammatory markers in meta-analyses · 4-8 weeks
Too few graded studies1 study
Skin health
Too few graded studies1 study
Vision & eye health
Too few graded studies1 study
By the numbers
Pulled from 55 studies with measurable effects
Likely real effects
92%
across studies
People studied
35k
typical study: 326 people
Strongest designs
50
33 pooled, 17 randomised
Showed benefit
80%
16/20 studies
How long studies ran
1–3 months
2
3+ months
4
Populations Studied
Heart failure patients3
Women with polycystic ovary syndrome1
Women with ovarian aging1
Women with diminished ovarian reserve1
Active research area
48 studies in the last 5 years · Latest meta-analysis: 2026
200720162026
1Meta-Analysisn=574 · large study2026
In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment.
Lyons S et al. · The Cochrane database of systematic reviews (2026)
Meta-analysis of seven studies demonstrated that pharmacological treatment probably makes little or no difference to scores on the ataxia rating scale after 12 months of treatment (SMD 0.02, 95% CI -0.23 to 0.26; I² = 42%; 7 studies, 513 participants; moderate-certainty evidence).
The evidence was very uncertain about the effects of treatment on IVSTd (MD -0.51, 95% CI -1.10 to 0.09; I² = 80%; 2 studies, 72 participants; very low-certainty evidence) and on ADL (MD -0.59, 95% CI -1.39 to 0.21; I² = 24%; 3 studies, 167 participants; very low-certainty evidence).
Meta-analysis of three studies showed that treatment probably improves upper limb dexterity (SMD -0.42, 95% CI -0.73 to -0.11; I² = 0%; 3 studies, 166 participants; moderate-certainty evidence).
3Clinical pregnancy ratesMeta-AnalysisCited 25×n=2,617 · very large study2024
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to...
Shang Y et al. · Advances in nutrition (Bethesda, Md.) (2024)
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates.
Appropriate antioxidant treatment should be offered at a low dose according to the patient's age and ovarian reserve.
This study was registered at PROSPERO as CRD42022359529.
5Inflammatory mediatorsMeta-AnalysisCited 13×n=1,517 · large study2023
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
Hou S et al. · Molecular nutrition & food research (2023)
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
6Clinical pregnancy rateMeta-AnalysisCited 11×n=2,323 · very large study2023
Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
Zhu F et al. · Reproductive biology and endocrinology : RB&E (2023)
Huge harm
← WorseNo effectBetter →
Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
CoQ10 was the best in improving the live birth rate (OR 2.36, 95% CI: 1.07 to 5.38).
DHEA increased the embryo implantation rate (OR 2.80, 95%CI: 1.41 to 5.57) and the high-quality embryo rate (OR 2.01, 95% CI: 1.07 to 3.78) and number of oocytes retrieved (WMD 1.63, 95% CI: 0.34 to 2.92) showed a greater advantage, with GH in second place.
7All-cause mortalityMeta-AnalysisCited 53×n=1,573 · large study2021
The included studies provide moderate-quality evidence that coenzyme Q10 probably reduces all-cause mortality and hospitalisation for heart failure.
Al Saadi T et al. · The Cochrane database of systematic reviews (2021)
Large benefit
← WorseNo effectBetter →
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
There was low-quality evidence of inconclusive results between the coenzyme Q10 and control groups for the risk of myocardial infarction (RR 1.62, 95% CI 0.27 to 9.59; 1 study, 420 participants), and stroke (RR 0.18, 95% CI 0.02 to 1.48; 1 study, 420 participants).
Coenzyme Q10 probably reduces hospitalisation related to heart failure (RR 0.62, 95% CI 0.49 to 0.78; 2 studies, 1061 participants; NNTB 9.7; moderate-quality evidence).
8Lipid profile improvementMeta-AnalysisCited 22×n=2,794 · very large study2022
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
Liu Z et al. · The Journal of clinical endocrinology and metabolism (2022)
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
9Clinical pregnancy rateMeta-AnalysisCited 64×n=6,510 · very large study2017
In this review, there was very low-quality evidence to show that taking an antioxidant may provide benefit for subfertile women, but insufficient evidence to draw any conclusions about adverse events.
Showell MG et al. · The Cochrane database of systematic reviews (2017)
This suggests that among subfertile women with an expected clinical pregnancy rate of 22%, the rate among women using antioxidants would be between 27% and 33%.
Heterogeneity was moderately high.There was insufficient evidence to determine whether there was a difference between the groups in rates of miscarriage (OR 0.79, 95% CI 0.58 to 1.08, P = 0.14, 18 RCTs, 2834 women, I2 = 23%, very low quality evidence).
This suggests that, among subfertile women with an expected miscarriage rate of 7%, use of antioxidants would be expected to result in a miscarriage rate of between 4% and 7%.
The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis.
Talandashti MK et al. · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2025)
In adults, compared with placebo, these supplements did not significantly affect other outcomes, and omega-3 supplementation did not yield a statistically significant reduction in any of these outcomes.
The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis.
Further clinical trials of high quality appear to be beneficial.
14Migraine duration reductionMeta-AnalysisCited 33×n=371 · medium study2021
CoQ10 appears to have beneficial effects in reducing duration and frequency of migraine attack.
Sazali S et al. · BMJ open (2021)
Noticeable benefit
← WorseNo effectBetter →
Likely real
There is no statistically significant reduction in severity of migraine headache with CoQ10 supplementation.
CoQ10 supplementation reduced the duration of headache attacks compared with the control group (MD: -0.19; 95% CI: -0.27 to -0.11; random effects; I2 statistic=0%; p<0.00001).
CoQ10 usage reduced the frequency of migraine headache compared with the control group (MD: -1.52; 95% CI: -2.40 to -0.65; random effects; I2 statistic=0%; p<0.001).
15Statin-induced myopathy symptomsMeta-AnalysisCited 117×n=575 · large study2018
Conclusions CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy.
Qu H et al. · Journal of the American Heart Association (2018)
Publication bias was evaluated by a funnel plot, Egger regression test, and the Begg-Mazumdar correlation test.
Twelve randomized controlled trials with a total of 575 patients were enrolled; of them, 294 patients were in the CoQ10 supplementation group and 281 were in the placebo group.
Conclusions CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy.
16All-cause mortality and heart failure outcomesMeta-AnalysisCited 6×n=33 · small study2024
According to the existing evidence, coenzyme Q10 reduces all-cause mortality, hospitalization for heart failure, New York Heart Association classification, and brain natriuretic peptide level and improves left ventricular ejection fraction and 6-min walk test result in those with heart failure without major adverse effects.
18Migraine attack frequency reductionMeta-AnalysisCited 31×n=221 · medium study2020
Conclusion: Pooled analyses of available randomized clinical trials suggest that Coenzyme Q10 supplementation may reduce the frequency of migraine attacks per month without affecting the severity or duration of migraine attacks.
Parohan M et al. · Nutritional neuroscience (2020)
Noticeable benefit
← WorseNo effectBetter →
Likely real
A meta-analysis of eligible studies was performed using the fixed effects model or the random effects model to estimate pooled effect size.
Coenzyme Q10 supplementation significantly reduced the frequency of migraine attacks (weighted mean difference: -1.87 attacks/month, 95% CI: -2.69 to -1.05, p < 0.001) without significant heterogeneity among the studies (I 2 = 36.6%, p = 0.192).
Results: Four randomized clinical trials with 221 participants were included.
19Myalgia symptoms improvementMeta-AnalysisCited 39×n=321 · medium study2020
This systematic review and meta-analysis did not demonstrate that CoQ10 supplementation was beneficial for patients with statin-associated muscle pain or improved adherence to statin therapy.
Kennedy C et al. · Atherosclerosis (2020)
No clear effect
← WorseNo effectBetter →
The meta-analysis did not demonstrate any benefit of CoQ10 supplementation in improving myalgia symptoms compared to placebo (weighted mean difference -0.42; 95% Confidence Interval [CI] -1.47 to 0.62).
Similarly, CoQ10 did not improve the proportion of patients remaining on the statin treatment (RR 0.99; 95%CI, 0.81 to 1.20).
This systematic review and meta-analysis did not demonstrate that CoQ10 supplementation was beneficial for patients with statin-associated muscle pain or improved adherence to statin therapy.
20Exercise and sport performanceSystematic ReviewCited 25×2022
However, clear approaches should be considered when conducting future research.
Drobnic F et al. · Nutrients (2022)
Overall, in the papers reviewed, although the data are inconclusive, they suggest that CoQ10 supplementation may be an interesting molecule in health or disease in individuals without a pathological deficiency and when used for optimising exercise performance.
Considering the results observed in the literature, and as a conclusion of this systematic review, we could say that it is an interesting molecule in sports performance.
However, clear approaches should be considered when conducting future research.