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Coq8.0
CoQ10 Research
Likely helps
322 peer-reviewed studies
What the evidence says
Likely helps
CoQ10 appears to help in 14 of 19 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 1993–2026 with a typical study size of 371 participants.
Based on 320 studies · 68 meta-analyses · 218 RCTs · 38,869 total participants
Confidence
High confidence
What the studies found
14helped1unclear4didn't help· 301 more without graded effect data
By outcome
Therapeutic & clinical
Mostly mechanism / observational49 studies
Heart & blood pressureImproved cardiac energy production and blood pressure within 4-8 weeks · 4-8 weeks
Mostly mechanism / observational33 studies
Glucose & metabolicSupports mitochondrial ATP production and metabolic efficiency · 8-12 weeks
Mostly mechanism / observational23 studies
Energy & fatigueReduced fatigue, especially if depleted · 2-4 weeks
Mostly mechanism / observational22 studies
Fertility & reproductiveMay support reproductive health and fertility markers · 4-12 weeks
Mixed evidence18 studies
Cholesterol & lipidsImproved cardiac energy production and blood pressure within 4-8 weeks · 4-8 weeks
Mostly mechanism / observational15 studies
InflammationReduces CRP and IL-6 inflammatory markers in meta-analyses · 4-8 weeks
Mostly mechanism / observational12 studies
Migraine & headache
Mostly mechanism / observational9 studies
Endurance & exercise performanceSupports mitochondrial ATP for endurance output · 4-8 weeks
Mostly mechanism / observational6 studies
Neuroprotection & brain agingSupports neuronal mitochondrial energy · 8-12 weeks
Mostly mechanism / observational6 studies
Safety profile
Mostly mechanism / observational5 studies
Skin healthReduced wrinkles in a small RCT of oral CoQ10 · 12 weeks · Modest improvement in skin smoothness/elasticity · 12 weeks
Mostly mechanism / observational4 studies
Vision & eye health
Mostly mechanism / observational3 studies
By the numbers
Pulled from 52 studies with measurable effects
Likely real effects
92%
across studies
People studied
39k
typical study: 371 people
Strongest designs
286
68 pooled, 218 randomised
Showed benefit
74%
14/19 studies
How long studies ran
3+ months
4
Populations Studied
Heart failure patients3
Poor ovarian response patients undergoing IVF-ET1
Women with polycystic ovary syndrome1
General population1
Active research area
100 studies in the last 5 years · Latest meta-analysis: 2026
199320092026
1Meta-Analysisn=574 · large study2026
In plain English: In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment.
Lyons S et al. · The Cochrane database of systematic reviews (2026)
Meta-analysis of seven studies demonstrated that pharmacological treatment probably makes little or no difference to scores on the ataxia rating scale after 12 months of treatment (SMD 0.02, 95% CI -0.23 to 0.26; I² = 42%; 7 studies, 513 participants; moderate-certainty evidence).
The evidence was very uncertain about the effects of treatment on IVSTd (MD -0.51, 95% CI -1.10 to 0.09; I² = 80%; 2 studies, 72 participants; very low-certainty evidence) and on ADL (MD -0.59, 95% CI -1.39 to 0.21; I² = 24%; 3 studies, 167 participants; very low-certainty evidence).
Meta-analysis of three studies showed that treatment probably improves upper limb dexterity (SMD -0.42, 95% CI -0.73 to -0.11; I² = 0%; 3 studies, 166 participants; moderate-certainty evidence).
2Clinical pregnancy rateMeta-Analysisn=2,323 · very large study2023
In plain English: Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
Zhu F et al. · Reproductive biology and endocrinology : RB&E (2023)
Huge harm
← WorseNo effectBetter →
Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
CoQ10 was the best in improving the live birth rate (OR 2.36, 95% CI: 1.07 to 5.38).
DHEA increased the embryo implantation rate (OR 2.80, 95%CI: 1.41 to 5.57) and the high-quality embryo rate (OR 2.01, 95% CI: 1.07 to 3.78) and number of oocytes retrieved (WMD 1.63, 95% CI: 0.34 to 2.92) showed a greater advantage, with GH in second place.
4Inflammatory mediatorsMeta-Analysisn=1,517 · large study2023
In plain English: This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
Hou S et al. · Molecular nutrition & food research (2023)
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
5Clinical pregnancy ratesMeta-Analysisn=2,617 · very large study2024
In plain English: The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to...
Shang Y et al. · Advances in nutrition (Bethesda, Md.) (2024)
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates.
Appropriate antioxidant treatment should be offered at a low dose according to the patient's age and ovarian reserve.
7Lipid profile improvementMeta-Analysisn=2,794 · very large study2022
In plain English: CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
Liu Z et al. · The Journal of clinical endocrinology and metabolism (2022)
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
8All-cause mortalityMeta-Analysisn=1,573 · large study2021
In plain English: The included studies provide moderate-quality evidence that coenzyme Q10 probably reduces all-cause mortality and hospitalisation for heart failure.
Al Saadi T et al. · The Cochrane database of systematic reviews (2021)
Large benefit
← WorseNo effectBetter →
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
There was low-quality evidence of inconclusive results between the coenzyme Q10 and control groups for the risk of myocardial infarction (RR 1.62, 95% CI 0.27 to 9.59; 1 study, 420 participants), and stroke (RR 0.18, 95% CI 0.02 to 1.48; 1 study, 420 participants).
Coenzyme Q10 probably reduces hospitalisation related to heart failure (RR 0.62, 95% CI 0.49 to 0.78; 2 studies, 1061 participants; NNTB 9.7; moderate-quality evidence).
10Live birth rateMeta-AnalysisCited 102×n=7,760 · very large study2020
In plain English: In this review, there was low- to very low-quality evidence to show that taking an antioxidant may benefit subfertile women.
Showell MG et al. · The Cochrane database of systematic reviews (2020)
Huge harm
← WorseNo effectBetter →
Likely real
Due to the very low-quality of the evidence we are uncertain whether antioxidants improve live birth rate compared with placebo or no treatment/standard treatment (odds ratio (OR) 1.81, 95% confidence interval (CI) 1.36 to 2.43; P < 0.001, I2 = 29%; 13 RCTs, 1227 women).
This suggests that among subfertile women with an expected live birth rate of 19%, the rate among women using antioxidants would be between 24% and 36%.
Low-quality evidence suggests that antioxidants may improve clinical pregnancy rate compared with placebo or no treatment/standard treatment (OR 1.65, 95% CI 1.43 to 1.89; P < 0.001, I2 = 63%; 35 RCTs, 5165 women).
11Migraine duration reductionMeta-Analysisn=371 · medium study2021
In plain English: CoQ10 appears to have beneficial effects in reducing duration and frequency of migraine attack.
Sazali S et al. · BMJ open (2021)
Noticeable benefit
← WorseNo effectBetter →
Likely real
There is no statistically significant reduction in severity of migraine headache with CoQ10 supplementation.
CoQ10 supplementation reduced the duration of headache attacks compared with the control group (MD: -0.19; 95% CI: -0.27 to -0.11; random effects; I2 statistic=0%; p<0.00001).
CoQ10 usage reduced the frequency of migraine headache compared with the control group (MD: -1.52; 95% CI: -2.40 to -0.65; random effects; I2 statistic=0%; p<0.001).
In plain English: Co-Q10 supplementation slightly but significantly reduced fasting blood glucose, but not fasting insulin and HbA1c.
Moradi M et al. · Archives of Iranian Medicine (2016)
Our preliminary meta-analysis on 14 eligible studies regarding the effect of Co-Q10 supplementation on FBG indicated a slightly significant decrement (SMD:-0.28 mg/d; 95% CI: -0.12, 0.04), with a substantial between-study heterogeneity.
The effect of Co-Q10 on HbA1c and fasting insulin was not significant.
Co-Q10 supplementation slightly but significantly reduced fasting blood glucose, but not fasting insulin and HbA1c.
18Meta-Analysis2015
Banach M, Serban C, Sahebkar A, Ursoniu S, Rysz J, Muntner P · Mayo Clin Proc (2015)