43 peer-reviewed studies · Evidence score: 7.5/10
Long Z et al. • Frontiers in immunology (2023)
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
Yang K et al. • Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Gao H et al. • Phytotherapy research : PTR (2024)
The results in patients with type 2 diabetes needed to be further supported by future research focusing on individuals with diabetes.
Djafari F et al. • Clinical nutrition ESPEN (2021)
The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures.
Hoang TPN et al. • Expert opinion on drug delivery (2026)
Formulation advances can significantly mitigate hesperidin's biopharmaceutical liabilities, with lipid-based systems, polymeric nanoparticles, and phytosomes emerging as leading strategies.
Martinez-Zapata MJ et al. • Cochrane Database of Systematic Reviews (2020)
Phlebotonics (including hesperidin) reduced edema, pain, and other symptoms of chronic venous insufficiency.
Mohammadi M et al. • Phytotherapy research : PTR (2019)
Future well-designed trials are still needed to confirm these results.
Han X et al. • European journal of medicinal chemistry (2025)
Few clinical trials have indicated that dietary supplements rich in hesperidin can improve cerebral blood flow, cognition, and memory performance.
Avila-Nava A et al. • The Journal of dairy research (2023)
In conclusion, supplementation with bioactive compounds had a positive impact which ranged from an increase in antioxidant capacity to a decrease in oxidative biomarkers such as malondialdehyde.
Monici Silva I et al. • European journal of oral sciences (2024)
Only naringin, quercetin, proanthocyanidins, and glutaraldehyde showed statistically significant efficacy over untreated controls.
Ranneh Y et al. • Nutrients (2024)
Still, the inconsistent results across the included RCTs require further clinical research to establish optimal dosage and duration.
Ungureanu LB et al. • Medicina (Kaunas, Lithuania) (2023)
Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.
Buzdağlı Y et al. • International journal of environmental health research (2023)
As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage.
Shams-Rad S et al. • British journal of clinical pharmacology (2020)
Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
Lorzadeh E et al. • Chemico-biological interactions (2019)
The present study suggests that although hesperidin supplementation significantly improves VCAM-1 levels; however, other inflammatory markers might not be affected.
Tamer F et al. • Thrombosis and haemostasis (2022)
We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance.
Tadros FJ et al. • Critical reviews in food science and nutrition (2022)
Steps can be taken in future research to improve the consistency of clinical study designs, methodology and outcomes.
Pompilio G et al. • Phlebology (2021)
Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD.
Nwadiugwu MC • Frontiers in public health (2020)
Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.
Gandhi GR et al. • Nutrients (2020)
Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.