Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren
Lmb5.8
Lemon Balm – Forschung
Hilft vermutlich
53 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Lemon Balm sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2002–2026 mit einer typischen Studiengröße von 71 Teilnehmenden.
Basierend auf 53 Studien · 4 Meta-Analysen · 33 RCTs · 10,246 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen1unklar· 51 weitere ohne bewertete Effektdaten
Sleep & insomniaVerbessertes Einschlafen und bessere Schlafqualität · 30-60 Minuten · Rosmarinsäure hemmt die GABA-Transaminase, um den Schlaf zu vertiefen · 1-2 Wochen
Überwiegend Mechanismus / Beobachtung12 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung10 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung9 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung8 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung7 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung6 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Depression & moodBeruhigende Wirkungen verringern Unruhe und verbessern die Stimmung · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Women's healthKann bei der Behandlung von Wechseljahrsbeschwerden wie Hitzewallungen und Stimmungsschwankungen helfen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Cold sores & HSV
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 18 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
67%
über Studien hinweg
Untersuchte Personen
10k
typische Studie: 71 Personen
Stärkste Designs
37
4 gepoolt, 33 randomisiert
Zeigte Nutzen
50%
1/2 Studien
Wie lange Studien liefen
1–4 Wochen
2
Untersuchte Populationen
General population2
Patients with herpes labialis1
Type 2 diabetes patients1
Patients with dyslipidemia1
Aktives Forschungsgebiet
27 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200220142026
1Herpes labialis healing time and symptom reductionSystematische Übersichtn=1,250 · large study2025
Einfach gesagt: Future well-designed, large-scale RCTs employing standardized methodologies are necessary to confirm these findings and to establish optimal treatment protocols for diverse patient populations (Inplasy protocol number: 202350038).
Anheyer M et al. · Journal of integrative and complementary medicine (2025)
Lemon balm preparations consistently reduced pain intensity and swelling, with some studies also reporting a significant decrease in lesion size compared with placebo or acyclovir.
Olive leaf extract demonstrated a statistically significant faster improvement in symptoms and a shorter healing time compared with acyclovir.
Discussion: The findings indicate that topical herbal therapies may provide effective and well-tolerated alternatives or adjuncts to conventional antiviral treatments for herpes labialis.
3Serum lipid profile improvementMeta-Analysen=302 · medium study2024
Einfach gesagt: The findings of this meta-analysis provide evidence that lemon balm may be administered as a safe and beneficial herbal medicine for reducing TC, TG and LDL levels.
Shahsavari K et al. · BMC complementary medicine and therapies (2024)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Could be chance
While it had no statistically significant effect on HDL level (SMD (95% CI): 0.336(-0.091, 0.767), p-value = 0.123).
The findings of this meta-analysis provide evidence that lemon balm may be administered as a safe and beneficial herbal medicine for reducing TC, TG and LDL levels.
According to the pooled results of 5 studies with a total of 302 patients, lemon balm intake had no significant effect on HDL level.
5GABA receptor interaction and sleep effectsSystematische Übersicht2021
Einfach gesagt: Currently available evidence suggests that herbal extracts may exert some of their hypnotic and anxiolytic activity through interacting with GABA receptors and modulating GABAergic signaling in the brain, but their mechanism of action in the treatment of insomnia is not completely understood.
Bruni O et al. · Nutrients (2021)
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states.
GABA receptors are the targets of many pharmacological treatments for insomnia, such as benzodiazepines.
Here, we perform a systematic analysis of studies assessing the mechanisms of action of various herbal medicines on different subtypes of GABA receptors in the context of sleep control.
Einfach gesagt: Further high-quality studies are needed to firmly establish the clinical efficacy of the lemon balm.
Ghazizadeh J et al. · Phytotherapy research : PTR (2021)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Based on meta-analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo (SMD: -0.98; 95% CI: -1.63 to -0.33; p = 0.003), (SMD: -0.47; 95% CI: -0.73 to -0.21; p = 0.0005) respectively, without serious side effects.
Current evidence suggests that lemon balm may be effective in improving anxiety and depressive symptoms, particularly in the acute setting.
Due to the high level of heterogeneity between studies, results should be interpreted with caution.
7Anxiolytic effects through GABA modulationSystematische Übersicht2018
Einfach gesagt: Collectively, the literature reveals preclinical and clinical evidence for various phytomedicines modulating GABA-pathways, with comparative anxiolytic effect to the current array of pharmaceuticals, along with good safety and tolerability profiles.
Savage K et al. · Phytotherapy research : PTR (2018)
An open-ended search to 5 July 2017 was conducted using MEDLINE (PubMed), Scopus, and Cochrane library online databases and performed in a stepped format from preclinical to clinical investigations.
Eligible studies must have had (a) in vitro evidence of GABA-modulating activity, (b) animal studies using anxiety models to test an anxiolytic effect, and (c) human clinical trials.
Ten phytomedicines were identified as having preclinical investigations showing interaction with the GABA system, in addition to human clinical trials: kava, valerian, pennywort, hops, chamomile, Ginkgo biloba, passionflower, ashwagandha, skullcap, and lemon balm.
Einfach gesagt: It is concluded that lemon balm has the potential to improve cognition and sleep quality; however, robust evidence is needed, as more rigorous trials are required.
Oliveira MVB, Garguerra JA, Lamas CB, Laurindo LF, Rodrigues VD, Sloan KP, Sloan LA, Chagas EFB, Guiguer EL, Detregiachi CRP, Miglino MA, Pereira ESBM, Valenti VE, Silva LR, Barbalho SM. · International journal of molecular sciences (2025)
Regarding sleep, a combination of lemon balm and valerian significantly improved sleep quality in postmenopausal women.
Isolated lemon balm extracts also reduced sleep disorders in cardiac patients.
When compared to citalopram, lemon balm enhanced the quality of life, including sleep quality.
9Pharmacological effects of lemon balmÜbersicht2025
Einfach gesagt: This review presents a critical synthesis of existing knowledge and future directions for integrating M. officinalis into nutraceutical, pharmaceutical, and cosmetic products.
Awlqadr FH, Altemimi AB, Qadir SA, Mohammed OA, Saeed MN, Hesarinejad MA, Lakhssassi N. · Food science & nutrition (2025)
Recent investigations have also shown its wide-ranging pharmacological potential, which includes antioxidant, antimicrobial, anti-inflammatory, neuroprotective, antiviral, antidepressant, anxiolytic, anticancer, cardioprotective, and cognitive-enhancing properties.
Furthermore, the traditional medicinal use of M. officinalis in managing neurodegenerative conditions such as stroke, epilepsy, dementia, and paralysis is increasingly supported by contemporary evidence, highlighting its therapeutic relevance in brain-related disorders.
However, further studies are necessary to refine extraction methods, standardize levels of bioactive compounds, and validate clinical applications.
Einfach gesagt: Results/conclusions Although further robust randomised controlled trials using lemon balm are required, existing research indicates that lemon balm holds promise as a calming agent exhibiting both anxiolytic and anti-depressant properties and can elicit cognitive and sleep-quality enhancement.
Mathews IM, Eastwood J, Lamport DJ, Cozannet RL, Fanca-Berthon P, Williams CM. · Nutrients (2024)
One herb that is receiving growing attention is lemon balm ( Melissa officinalis L.) which has received considerable interest for its influence on the brain.
Lemon balm boasts an array of phytochemicals, including rosmarinic acid, citral, oleanolic acid, and ursolic acid, which are believed to underpin these effects on psychological well-being.
Pharmacological evidence from animal and cellular work reveals that lemon balm and its components may modulate several brain signalling pathways, including GABAergic, cholinergic, and serotonergic systems.
12Evidence synthesis for Melissa officinalisSystematische Übersicht2005
Einfach gesagt: An evidence-based systematic review including written and statistical analysis of scientific analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetic/dynamics, interactions, adverse effect, toxicology, and dosing.
Ulbricht C et al. · Journal of herbal pharmacotherapy (2005)
An evidence-based systematic review including written and statistical analysis of scientific analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetic/dynamics, interactions, adverse effect, toxicology, and dosing.
Further research warranted to confirm findings
13RCTn=44 · small study2023
Einfach gesagt: After 12-week the mean change of depression and anxiety scores were statistically significant between the two groups (p < 0.001 and p = 0.04, respectively), but no significant differences were observed in FBS, hs-CRP, anthropometric indices, sleep quality, and blood pressure.
Safari M et al. · BMC complementary medicine and therapies (2023)
M. officinalis extract 700 mg/day significantly reduced depression (p < 0.001) and anxiety (p = 0.04) scores versus placebo over 12 weeks in type 2 diabetes patients with depression
No significant between-group differences were seen for fasting blood sugar, hs-CRP, anthropometric indices, sleep quality, or blood pressure
14sleep quality and anxiety reductionMeta-Analysen=918 · large study2024
Einfach gesagt: This meta-analysis consolidates recent RCT evidence on lemon balm for sleep and anxiety, the two primary categories for this supplement.
Einfach gesagt: The results revealed that M. Officinalis L. may be recommended for improving the quality of life of menopausal women with sleep disturbance.
Shirazi M et al. · Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2021)
The mean for all MENQOL domain scores were significantly improved in the M. officinalis group compared with citalopram and placebo.
M. Officinalis L. (combined with fennel fruit extract) may be recommended for improving the quality of life of menopausal women with sleep disturbance.