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Mn4.0
Manganese – Forschung
Hilft wahrscheinlich
33 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Manganese scheint in 3 von 4 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1970–2026 mit einer typischen Studiengröße von 1,113 Teilnehmenden.
Basierend auf 33 Studien · 10 Meta-Analysen · 6 RCTs · 346,436 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
3geholfen1unklar· 29 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung16 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung5 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung4 Studien
Women's health
Überwiegend Mechanismus / Beobachtung4 Studien
Safety & neurotoxicity
Überwiegend Mechanismus / Beobachtung3 Studien
Cognitive function
Zu wenige bewertete Studien2 Studien
Inflammation
Zu wenige bewertete Studien2 Studien
Bone healthCofaktor für Knochenmatrix-Enzyme, aber keine Supplementierungsstudien zeigen einen Nutzen bei ausreichend versorgten Erwachsenen · 8-12 weeks
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 18 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
346k
typische Studie: 1113 Personen
Stärkste Designs
16
10 gepoolt, 6 randomisiert
Zeigte Nutzen
75%
3/4 Studien
Untersuchte Populationen
Pregnant women2
Alzheimer's disease patients1
Osteoarthritis patients1
Asian cohort with hepatocellular carcinoma1
Aktives Forschungsgebiet
22 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
197019982026
1Blood manganese concentration in preeclampsia vs controlMeta-Analysen=1,113 · large study2024
Einfach gesagt: In conclusion, a low blood level of Mn may be associated with PE in pregnant women.
Wu A et al. · Biological trace element research (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Pooled results showed that compared to normotensive control, women with PE had significantly lower blood Mn concentration (standardized mean difference: -0.36, 95% confidence interval: -0.50 to -0.22, p < 0.001; I2 = 67%).
Finally, pooled results of three studies showed that a high level of blood Mn was related to a low risk of PE with blood Mn analyzed in continuous (risk ratio [RR]: 0.71, 95% CI: 0.59 to 0.85, p < 0.001; I2 = 0%) and categorized variables (RR: 0.50, 95% CI: 0.30 to 0.82, p = 0.006; I2 = 32%).
In conclusion, a low blood level of Mn may be associated with PE in pregnant women.
2Trace element alterations in Alzheimer's dementiaMeta-Analysen=73 · small study2023
Einfach gesagt: In a further meta-analysis, standardized mean differences (SMDs) of 13 elements were calculated to evaluate their altered in AD patients, including copper, iron, zinc, selenium, manganese, lead, al...
Li K et al. · Environmental pollution (Barking, Essex : 1987) (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
In a further meta-analysis, standardized mean differences (SMDs) of 13 elements were calculated to evaluate their altered in AD patients, including copper, iron, zinc, selenium, manganese, lead, aluminum, cadmium, chromium, arsenic, mercury, cobalt, and manganese.
We identified four trace elements-copper (serum), iron (plasma), zinc (hair), and selenium (plasma)-altered in AD patients, with SMDs of 0.37 (95% confidence interval [CI]: 0.10, 0.65), -0.68 (95% CI: -1.34, -0.02), -0.35 (95% CI: -0.62, -0.08), and -0.61 (95% CI: -0.97, -0.25), respectively.
Finally, we formed a database of various trace element levels in AD patients and healthy controls.
4Osteoarthritis association with serum trace elementsMeta-Analyse2024
Einfach gesagt: The study suggests that there is an association between the occurrence of OA and variations in serum levels of copper, manganese, cadmium, and selenium.
Shi H et al. · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2024)
The study suggests that there is an association between the occurrence of OA and variations in serum levels of copper, manganese, cadmium, and selenium.
Elevated serum copper may play a pivotal role.
Further research is needed to explore the therapeutic potential of TE level modulation in OA management.
Einfach gesagt: While more evidence from prospective cohorts is needed, future studies should use novel statistical approaches to evaluate relative contribution of Mn on MetS risk along with other inter-related exposures.
Wong MMH et al. · Nutrients (2022)
Therefore, the present review examined the association between dietary and environmental Mn exposure, and MetS risk.
A total of nine cross-sectional studies and three case-control studies were included, which assessed Mn from diet, serum, urine, and whole blood.
While more evidence from prospective cohorts is needed, future studies should use novel statistical approaches to evaluate relative contribution of Mn on MetS risk along with other inter-related exposures.
7Cognitive performance decline from manganese exposureMeta-Analysen=18 · very small study2023
Einfach gesagt: Differences between the exposure and control groups in cognitive testing were synthesized by effect size Hedge's g.
Vlasak T et al. · Environmental pollution (Barking, Essex : 1987) (2023)
Differences between the exposure and control groups in cognitive testing were synthesized by effect size Hedge's g.
We included 18 studies with 75 effect sizes comparing n = 888 controls and 1092 exposed participants.
We provide results of impaired cognitive functions for working adults exposed to manganese in processing speed, attention, working memory, reaction time and visual attention.
8Serum iron, magnesium, copper, and manganese levels in alcoholismSystematische Übersicht2019
Einfach gesagt: Frequent comorbidities and mutual relationships between the elements in question are just some of the complications in the study of this topic.
Grochowski C et al. · Molecules (Basel, Switzerland) (2019)
Again, the causes for this are numerous and include malnutrition, drug abuse, respiratory alkalosis, and gastrointestinal problems, apart from the direct influence of excessive alcohol intake.
Unfortunately, studies regarding the levels of both copper and manganese in the case of (alcoholic) liver disease are scarce and often contradictory.
Still, the authors have attempted to summarize and give a thorough insight into the literature available, bearing in mind the difficulties involved in the studies.
11Neuropsychiatric effects of metal toxicityÜbersicht2021
Einfach gesagt: This systematic-review examined the effects of Manganese.
Tarnacka B et al. · International journal of molecular sciences (2021)
They also play vital roles in the central nervous system as significant cofactors for several enzymes, including the antioxidant enzyme superoxide dismutase (SOD) and other enzymes that take part in the creation and breakdown of neurotransmitters in the brain.
In the present review, the authors focus on neurological disorders with psychiatric signs associated with copper, iron, and manganese excess and the diagnosis and potential treatment of such disorders.
Einfach gesagt: Here, we present an overview of the intake, absorption, and transport of four essential elements (Fe, Zn, Cu, Mn) and one non-essential element (aluminum: Al) in food and their connections with the pathogenesis of neurodegenerative diseases based on metal-protein, and metal-metal cross-talk.
Kawahara M et al. · Nutrients (2023)
The disease-related amyloidogenic proteins can regulate metal homeostasis at the synapses, and thus loss of the protective functions of these amyloidogenic proteins causes neurodegeneration.
Meanwhile, metal-induced conformational changes of the amyloidogenic proteins contribute to enhancing their neurotoxicity.
Moreover, excess Zn and Cu play central roles in the pathogenesis of vascular-type senile dementia.
14Type 2 diabetes riskMeta-Analysen=165,194 · very large study2026
Einfach gesagt: Our meta-analysis suggested that increasing Mn intake may lower T2D risk, potentially exhibiting a dose-response non-linear pattern, although not corroborated by UK Biobank analysis.
Gebretsadik GG et al. · The journal of nutrition, health & aging (2026)
Kein klarer Effekt
← SchlechterKein EffektBesser →
High Mn intake (Q5) was not significantly associated with lower risk of T2D as compared to Q1 (adjusted HR 0·91; 95% CI 0·82, 1.01, Ptrend = 0·07).
The dose-response meta-analysis revealed a 4% reduction in T2D risk with each mg/day increase in Mn intake (pooled RR 0·96; 95% CI 0·94, 0·99), with potential non-linearity (Pnonlinear< 0.01).
Q5 Mn intake was not significantly associated with reduced risk of CVD (adjusted HR 0·99; 95% CI 0·92, 1.05; Ptrend = 0·61) or CVD mortality (adjusted HR 0·85; 95% CI 0·64, 1.13; Ptrend = 0·66).
Einfach gesagt: The current evidence on the involvement of Mn in metabolic diseases, such as type 2 diabetes mellitus/insulin resistance, osteoporosis, obesity, atherosclerosis, and non-alcoholic fatty liver disease, was collected and discussed.
Baj J et al. · International journal of molecular sciences (2023)
People with genetic diseases associated with a mutation in the gene associated with impaired Mn excretion, kidney disease, iron deficiency, or a vegetarian diet are at particular risk of excessive exposure to Mn.
The disturbed homeostasis of Mn in the body has been connected with susceptibility to neurodegenerative diseases, fertility, and infectious diseases.
The current evidence on the involvement of Mn in metabolic diseases, such as type 2 diabetes mellitus/insulin resistance, osteoporosis, obesity, atherosclerosis, and non-alcoholic fatty liver disease, was collected and discussed.
16Relationship between manganese levels and epilepsySystematische Übersicht2007
Einfach gesagt: The lack of evidence indicating whether this is a cause or an effect of the convulsions clearly justifies more detailed follow-up investigations in humans.
Gonzalez-Reyes RE et al. · Brain research reviews (2007)
Of the remaining nine, six were in humans and three in rodents.
At present, there is no satisfactory explanation for the relationship between low manganese levels and the presence of convulsions.
The lack of evidence indicating whether this is a cause or an effect of the convulsions clearly justifies more detailed follow-up investigations in humans.