40 peer-reviewed studies · Evidence score: 8.5/10
Liu R et al. • Advances in Nutrition (2024)
All intervention groups including L+Z+MZ significantly increased MPOD compared to placebo.
Wilson LM et al. • Advances in nutrition (Bethesda, Md.) (2021)
Our objective was to determine a minimum concentration of lutein/zeaxanthin intake that is associated with a statistically significant and/or clinically important change in macular pigment optical ...
Arunkumar R et al. • Advances in experimental medicine and biology (2023)
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Li X et al. • Nutrition reviews (2023)
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Lem DW et al. • Nutrients (2021)
The data suggest that carotenoid vitamin therapy exerts synergic neuroprotective benefits and has the capacity to serve adjunctive therapy in the management of glaucoma.
Lem DW et al. • Nutrients (2021)
These findings provide a strong molecular basis and a line of evidence that suggests carotenoid vitamin therapy may offer enhanced neuroprotective effects with therapeutic potential to function as an adjunct nutraceutical strategy for management of diabetic retinopathy.
Li B et al. • Methods in enzymology (2022)
Intraretinal levels of these carotenoids are inversely associated with the risk of age-related macular degeneration (AMD), and oral supplementation with these carotenoids can significantly reduce A...
García-Romera MC et al. • Physiology & behavior (2022)
Dietary lutein and zeaxanthin intake increased MPOD in six of the seven clinical trials and significantly improved most of the cognitive functions studied.
Wang H et al. • Journal of Alzheimer's disease : JAD (2022)
The diet supplements of L + Z or L + Z+MZ are associated with better cognitive functioning, which may be via their beneficial effects on the vision.
Ma L et al. • Nutrients (2016)
This meta-analysis revealed that lutein, zeaxanthin and meso-zeaxanthin supplementation improved MPOD both in AMD patients and healthy subjects with a dose-response relationship.
Arunkumar R et al. • Biochimica et biophysica acta. Molecular and cell biology of lipids (2020)
The MP carotenoids filter high-intensity, short-wavelength visible light and are powerful antioxidants in a region vulnerable to light-induced oxidative stress.
Widomska J et al. • Nutrients (2020)
In this review, we discuss how the differences in the specific properties of lutein and zeaxanthin could help explain the preferential accumulation of zeaxanthin in the most vulnerable region of the macula.
Demmig-Adams B et al. • Molecules (Basel, Switzerland) (2020)
The question of an optimal dietary antioxidant supply is evaluated in the context of the dual roles of both oxidants and antioxidants, in all vital functions of living organisms, and the profound impact of individual and environmental context.
Bernstein PS et al. • Progress in retinal and eye research (2016)
Next, we turn to clinical evidence supporting functional benefits of these carotenoids in normal eyes and for their potential protective actions against ocular disease from infancy to old age.
Mares J • Annual review of nutrition (2016)
Accumulating evidence about variable interindividual response to dietary intake of these carotenoids, based on genetic or metabolic influences, suggests that there may be subgroups that benefit from higher levels of intake and/or alternate strategies to improve lutein and zeaxanthin status.
Nolan JM et al. • Eye (London, England) (2013)
Certainly, the narrative that retinal MZ is derived wholly and solely from retinal L needs to be revisited.
Ahmed SS et al. • Survey of ophthalmology (2005)
New and standardized methods of assessing macular pigment density are discussed and future areas of research to further our understanding of macular xanthophylls as they pertain to age-related macular degeneration are highlighted.
Stringham NT et al. • Nutrition, metabolism, and cardiovascular diseases : NMCD (2024)
Our data show that L, Z, & MZ supplementation results in decreased serum IL-1β, TNF-α, and OxLDL.
Akuffo KO et al. • Investigative ophthalmology & visual science (2017)
Antioxidant supplementation in patients with nonadvanced age-related macular degeneration results in significant increases in macular pigment and improvements in CS and other measures of visual function. (Clinical trial, http://www.isrctn.com/ISRCTN13894787).
Nolan JM et al. • Investigative Ophthalmology & Visual Science (2016)
Supplementation with all three macular carotenoids significantly improved macular pigment and visual function.