40 peer-reviewed studies · Evidence score: 9/10
Zhao G et al. • Reproductive biology and endocrinology : RB&E (2025)
Chromium, inositol, and Omega-3 were found to be beneficial for improving lipid profile.
Hu X et al. • PeerJ (2023)
Carnitine was relatively effective in reducing body mass, while chromium, Omega-3, and selenium were beneficial for improving glucose metabolism.
Shang Y et al. • Advances in nutrition (Bethesda, Md.) (2024)
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to...
Motuhifonua SK et al. • The Cochrane database of systematic reviews (2023)
Evidence from seven studies shows that antenatal dietary supplementation with myo-inositol during pregnancy may reduce the incidence of gestational diabetes, hypertensive disorders of pregnancy and preterm birth.
Fitz V et al. • The Journal of clinical endocrinology and metabolism (2024)
The evidence supporting the use of inositol in the management of PCOS is limited and inconclusive.
Lin L et al. • Journal of ovarian research (2024)
Metformin and myoinositol may reduce OHSS risk in PCOS patients but did not significantly improve pregnancy outcomes.
Greff D et al. • Reproductive biology and endocrinology : RB&E (2023)
Inositol is an effective and safe treatment in PCOS.
Zhao H et al. • Reproductive health (2021)
Ours is the first study to report that for women with PCOS, myo-inositol combined with D-chiro-inositol and metformin combined with thiazolidinediones appear superior to metformin alone in improving insulin resistance and decreasing total testosterone.
Wei J et al. • Nutrients (2022)
In conclusion, 4 g MI nutritional supplementation per day during early pregnancy may reduce GDM incidence and severity, therefore may be a practical and safe approach for the prevention of GDM.
Showell MG et al. • The Cochrane database of systematic reviews (2017)
In this review, there was very low-quality evidence to show that taking an antioxidant may provide benefit for subfertile women, but insufficient evidence to draw any conclusions about adverse events.
Morley LC et al. • The Cochrane database of systematic reviews (2017)
Our updated review suggests that metformin alone may be beneficial over placebo for live birth, although the evidence quality was low.
Kelly FA et al. • Endocrine (2025)
In this meta-analysis of RCTs, combination therapy was associated with cycle regularization and reduction in hirsutism and LH/FSH ratio compared to metformin monotherapy.
Zhang JQ et al. • European review for medical and pharmacological sciences (2022)
Compared with metformin, the suitable supplemental dosage of myo-ins may be helpful in lowering levels of TG and avoiding adverse events (AEs).
Gabriel FC et al. • Nutritional neuroscience (2023)
The 27 interventional studies mainly focused on fatty acids, micronutrients and N-acetylcysteine (NAC).
Fatima K et al. • Irish journal of medical science (2023)
Our meta-analysis comparing hormonal and metabolic parameters between MET and MI did not show much significant difference, indicating both drugs are equally beneficial in improving metabolic and hormonal parameters in patients with PCOS.
Hoffman J et al. • The Cochrane database of systematic reviews (2021)
There was insufficient evidence from meta-analysis to confirm or refute the efficacy of any agent or class of medication for the treatment of TTM in adults, children or adolescents.
Guo X et al. • Journal of diabetes and its complications (2018)
Myo-inositol is related to lower incidence of GDM, as well as fasting, 1h, and 2h OGTT value, in pregnant women with high risk of this condition.
Unfer V et al. • Gynecological Endocrinology (2017)
Myo-inositol significantly improved ovulation rate and metabolic parameters in PCOS.
Pandey C et al. • Nutrients (2024)
The available evidence is insufficient to recommend nutrient supplementation to improve female infertility in women trying to conceive naturally and those utilising MAR.
Moslehi N et al. • Nutrition reviews (2023)
There was no high-certainty evidence that diets alone in women with PCOS improved health or reproductive outcomes.