Rl8.0

Raspberry Leaf Research

40 peer-reviewed studies · Evidence score: 8/10

Historical Review of Ethnopharmacology in Karelia (1850s-2020s): Herbs and healers

Kolosova V et al. • Journal of ethnopharmacology (2022)

Karelians and Russians are very disproportionally represented in the literature due to the lack of interest in the folk medicine of Russians in Karelia, in contrast to that of Karelians.

Karelians and Russians are very disproportionally represented in the literature due to the lack of interest in the folk medicine of Russians in Karelia, in contrast to that of Karelians.
The disparity does not allow adequate comparison, but nonetheless the available data demonstrate that the remedies shared by both ethnic groups are quite few.
The review also contributes to research on the relationship of folk medicine and various state institutions in Russia/the Soviet Union.

Systematic Reviewn=104

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Ellagitannins from red raspberry (Rubus idaeus L.): a comprehensive review on chemistry characteristics and beneficial effects

Tao M et al. • Food & function (2026)

It aims to provide the food science and nutrition community with an authoritative reference on ellagitannins in red raspberry and to guide their development and application as core ingredients for next-generation functional foods and nutraceuticals.

In red raspberry (Rubus idaeus L.), ellagitannins constitute the predominant class of polyphenols, accounting for 53-76% of the total polyphenolic content, and their health-promoting potential is becoming increasingly evident.
This review systematically delineates the chemical structures of ellagitannins, extraction and analytical techniques, in vivo metabolic pathways, and their multiple biological activities.
It aims to provide the food science and nutrition community with an authoritative reference on ellagitannins in red raspberry and to guide their development and application as core ingredients for next-generation functional foods and nutraceuticals.

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Comprehensive characterization of Rubus idaeus L. Polysaccharides: Extraction, purification, structural diversity, biological efficacy, and structure-activity relationships

Gao S et al. • Journal of ethnopharmacology (2026)

RP is among the key bioactive constituents of Rubus idaeus L.

RP is among the key bioactive constituents of Rubus idaeus L.
This review provides a comprehensive summary of the extraction, isolation, purification, biological activities, and structure-activity relationships of RP, offering valuable reference and support for their applications in pharmaceuticals, food products, nutraceuticals, and cosmetics.
Further research warranted to confirm findings

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Raspberry polysaccharide extraction, purification, structural characterization, and biological activity research progress: A review

Zhao F et al. • International journal of biological macromolecules (2026)

Consequently, elucidating the intricate process-structure-activity relationship is paramount for their effective utilization.

Consequently, elucidating the intricate process-structure-activity relationship is paramount for their effective utilization.
This review provides a comprehensive and systematic synthesis of current research on raspberry polysaccharides, encompassing advanced extraction and purification techniques, methods for structural characterization, underlying mechanisms of biological activity, and potential applications.

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The road for red raspberry seeds valorization: A comprehensive review on the chemical composition, extraction techniques, bioactivity and applications

Lopes P et al. • Food chemistry (2025)

Current commercial exploitation of RS biocomponents is limited to cosmetics despite RS exploration for food fortification by nutritional enrichment and oil stabilization.

Current commercial exploitation of RS biocomponents is limited to cosmetics despite RS exploration for food fortification by nutritional enrichment and oil stabilization.
The findings underscore the importance of further research to fully realize the potential of RS.

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Herbal Medicines for Induction of Labour: A Systematic Review and Meta-Analysis

Hall HG, McKenna LG, Griffiths DL • Women and Birth (2020)

Evidence for raspberry leaf tea in labor is inconclusive due to heterogeneity and small sample sizes in available trials.

Insufficient evidence to recommend or discourage raspberry leaf use in pregnancy
Some studies suggest shortened second stage of labor, but quality of evidence is low
No significant adverse events reported in any included studies

Meta-Analysisn=600

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Aromatic plants as cosmeceuticals: benefits and applications for skin health

Olivero-Verbel J et al. • Planta (2024)

This systematic-review examined the effects of Marshmallow Root.

Osbeck (Rutaceae), emphasizing their potential in skincare formulations and their role in promoting health and rejuvenation.
Further research warranted to confirm findings

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Raspberry Leaves and Extracts-Molecular Mechanism of Action and Its Effectiveness on Human Cervical Ripening and the Induction of Labor

Socha MW et al. • Nutrients (2023)

The currently available data indicate a weak effect of raspberry leaf extracts on labor induction and, at the same time, their possible negative impact on cervical ripening.

The majority of women apply raspberry leaves during pregnancy to induce and ease labor.
However, it has not been possible to determine the exact effect of using raspberry extracts on the course of childbirth and the perinatal period.
Additionally, it is unclear whether this herb has only positive effects.

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A Review on Berry Seeds-A Special Emphasis on Their Chemical Content and Health-Promoting Properties

Sławińska N et al. • Nutrients (2023)

However, many preparations and compounds still lack appropriate evidence for their effectiveness in vivo, so their activity should first be assessed in animal studies and clinical trials.

Last search was conducted on 16.01.2023.
Various preparations from berry seeds are valuable sources of bioactive phytochemicals and could be used as functional foods or to make pharmaceuticals or cosmetics.
Some products, like oil, flour, or extracts, are already available on the market.

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Raspberry (Rubus idaeus L.), a Promising Alternative in the Treatment of Hyperglycemia and Dyslipidemias

Piña-Contreras N et al. • Journal of medicinal food (2022)

According to the results, raspberry can be included in the nonpharmacological treatment of hyperglycemia and dyslipidemias; however, further research is considered necessary.

However, regarding the lipid-lowering effect, the results were heterogeneous, mainly in terms of stabilization in triglyceride levels.
However, a reduction in cholesterol and low-density lipoprotein levels is reported, as well as an increase in high-density lipoproteins.
According to the results, raspberry can be included in the nonpharmacological treatment of hyperglycemia and dyslipidemias; however, further research is considered necessary.

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Biophysical effects, safety and efficacy of raspberry leaf use in pregnancy: a systematic integrative review

Bowman R et al. • BMC complementary medicine and therapies (2021)

Many women use raspberry leaf in pregnancy to facilitate labour and birth.

Human studies have not shown any harm or benefit though one study demonstrated a clinically meaningful (though non-statistically significant) reduction in length of second stage and augmentation of labour in women taking raspberry leaf.
Many women use raspberry leaf in pregnancy to facilitate labour and birth.
The evidence base supporting the use of raspeberry leaf in pregnancy is weak and further research is needed to address the question of raspberry leaf's effectiveness.

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Herbal Medicinal Product Use During Pregnancy and the Postnatal Period: A Systematic Review

Muñoz Balbontín Y et al. • Obstetrics and gynecology (2019)

The use of herbal medicinal products during pregnancy and the postnatal period should be discouraged until robust evidence of safety is available.

Use of almond oil was associated with preterm birth (odds ratio 2.09, 95% CI 1.07-4.08), oral raspberry leaf was associated with cesarean delivery (adjusted odds ratio [AOR] 3.47, 95% CI 1.45-8.28); heavy licorice use was associated with early preterm birth by 3.07-fold (95% CI 1.17-8.05).
African herbal medicine mwanaphepo was associated with maternal morbidity (AOR 1.28; 95% CI 1.09-1.50), and neonatal death or morbidity.
The use of herbal medicinal products during pregnancy and the postnatal period should be discouraged until robust evidence of safety is available.

Systematic Reviewn=74

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Raspberry Leaf and Its Effect on Labour: Safety and Efficacy

Bowman R, Taylor J, Muggleton S, Davis D • Complementary Therapies in Clinical Practice (2021)

Raspberry leaf is widely used by pregnant women, but robust evidence for its efficacy in shortening labor remains limited.

Raspberry leaf consumption is common among pregnant women (up to 52% in some populations)
No evidence of harm to mother or baby when consumed from 32 weeks gestation
Potential uterotonic effects warrant further well-designed RCTs

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Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Nirumand MC et al. • International journal of molecular sciences (2018)

Further investigations are required to confirm the safety and efficacy of these compounds.

The main underlying mechanisms of these dietary plants and their isolated phytonutrients in the management of urolithiasis include diuretic, antispasmodic, and antioxidant activity, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals.
The results as presented in this review demonstrate the promising role of dietary plants and phytophenols in the prevention and management of kidney stones.
Further investigations are required to confirm the safety and efficacy of these compounds.

Meta-Analysis

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Phenolic Composition, Mineral Content, and Beneficial Bioactivities of Leaf Extracts from Black Currant (Ribes nigrum L.), Raspberry (Rubus idaeus), and Aronia (Aronia melanocarpa)

Staszowska-Karkut M et al. • Nutrients (2020)

Therefore, the leaves of berry bushes seem to be a promising source of substances that can be used as replacements for synthetic agents in the treatment and prevention of lifestyle diseases.

This was reviewed and discussed in this article.
The mineral content of their leaves was also summarized because minerals constitute a significant component of plant infusions.
It has been shown that high antioxidant and biological activity of leaf extracts results from the presence of active phenolic compounds, which occur in definitely higher amounts than in fruits.

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Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links

Burton-Freeman BM et al. • Advances in nutrition (Bethesda, Md.) (2016)

The body of research is growing and supports a potential role for red raspberries in reducing the risk of metabolically based chronic diseases.

In vitro and in vivo studies have revealed various mechanisms through which anthocyanins and ellagitannins (via ellagic acid or their urolithin metabolites) and red raspberry extracts (or the entire fruit) could reduce the risk of or reverse metabolically associated pathophysiologies.
To our knowledge, few studies in humans are available for evaluation.
The body of research is growing and supports a potential role for red raspberries in reducing the risk of metabolically based chronic diseases.

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Volatile compounds of raspberry fruit: from analytical methods to biological role and sensory impact

Aprea E et al. • Molecules (Basel, Switzerland) (2015)

Finally a summary of research done so far and our vision for future research lines are reported.

Two additional tables report the glycosidic bond and enantiomeric distributions of the volatile compounds investigated up to now in raspberry fruit.
Studies on the development and evolution of volatile compounds during fruit formation, ripening and senescence, and genetic and environmental influences are also reviewed.
Finally a summary of research done so far and our vision for future research lines are reported.

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Herb remedies during pregnancy: a systematic review of controlled clinical trials

Dante G et al. • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2013)

Despite the widespread, popular use of herbal remedies during pregnancy, too few studies have been devoted to specific clinical investigations.

Despite the widespread, popular use of herbal remedies during pregnancy, too few studies have been devoted to specific clinical investigations.
With the exception of ginger, there is no data to support the use of any other herbal supplement during pregnancy.
Further research warranted to confirm findings

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Plants used for making recreational tea in Europe: a review based on specific research sites

Sõukand R et al. • Journal of ethnobiology and ethnomedicine (2013)

Moreover, regional studies dedicated to the study of local plants used for making recreational tea are important to improve our understanding of their selection criteria, cultural importance and perceived properties in Europe and abroad.

The clear favorite was Origanum vulgare L., mentioned in 61% of the regions.
Regionally, other important taxa included Rubus idaeus L. in eastern Europe, Chamaemelum nobile (L.) All. in southern Europe and Rosa canina L. in central Europe.
Future research on the pharmacological, nutritional and chemical properties of the plants most frequently used in the tea-making process is essential to ensure their safety and appropriateness for daily consumption.

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Complementary and alternative medicine for induction of labour

Hall HG et al. • Women and birth : journal of the Australian College of Midwives (2012)

More research is needed to establish the safety and efficacy of CAM modalities.

More research is needed to establish the safety and efficacy of CAM modalities.
Midwives should develop a good understanding of these therapies, including both the benefits and risks, so they can assist women to make appropriate decisions.
Further research warranted to confirm findings

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