44 peer-reviewed studies · Evidence score: 7.5/10
Baladia E et al. • Nutrients (2024)
In summary, the findings indicate that individuals suffering from some type of cancer consumed less broccoli, suggesting a protective biological effect of broccoli on cancer.
Siafis S et al. • Molecular autism (2022)
Some medications could improve core symptoms, although this could be likely secondary to the improvement of associated symptoms.
Persico AM et al. • Progress in neuro-psychopharmacology & biological psychiatry (2025)
However, a small subset of compounds, including N-acetylcysteine, folinic acid, l-carnitine, coenzyme Q10, sulforaphane, and metformin may already be considered, with due caution, for clinical use,...
Campisi M et al. • Advances in nutrition (Bethesda, Md.) (2025)
Notably, nearly 90% of studies reported DNMT inhibition-often dose- and time-dependent.
Long J et al. • BMC pharmacology & toxicology (2025)
Sulforaphane may serve as an efficacious and safe adjunctive therapy for ASD, mediated by its anti-oxidant and anti-inflammatory effects along with the modulation of autophagy.
Monteiro EB et al. • Life sciences (2023)
These findings provide new insights concerning preclinical strategies for treating kidney disease or kidney failure with SFN supplements and should stimulate interest in clinical evaluations of SFN in patients with kidney disease.
Kassar O et al. • BMC psychiatry (2025)
The study provides initial insights into sulforaphane's potential therapeutic effects in schizophrenia, showing modest improvements in general psychopathology and negative symptoms, with favorable metabolic changes and lower discontinuation rates.
Guo J et al. • Brain & development (2025)
The results of this meta-analysis showed that sulforaphane significantly improved irritability and hyperactivity symptoms, suggesting that sulforaphane has the potential for the combined treatment ...
Josa E et al. • Nutrients (2024)
These results suggest that bioactive compounds of plant-based foods and medicinal plants have promising effects in terms of preventing or treating CKD progression and appear to improve inflammation and antioxidant capacity and support cardiovascular benefits and renoprotective effects; however, it is recommended that further studies be carried out.
Galanty A et al. • International journal of molecular sciences (2024)
Instead, they indicate that including brassica vegetables in the daily diet, particularly when accompanied by adequate iodine intake, poses no adverse effects on thyroid function.
Cascajosa-Lira A et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)
SFN has potential clinical applications as a chemoprotective agent.
Masoom M et al. • Polimery w medycynie (2024)
If its effectiveness is substantiated, SFN could complement or offer an alternative to existing preventive measures against skin cancer.
Ilaghi M et al. • PloS one (2024)
Although more research is needed to determine the efficacy and optimal dose of anti-inflammatory and antioxidant dietary supplements against air pollution toxicity, this low-cost preventative strategy has the potential to offer protection against outcomes of air pollution exposure.
Ngo SNT et al. • Anti-cancer agents in medicinal chemistry (2021)
Current preclinical evidence strongly supports the role of sulforaphane and other ITCs as potential therapeutic agents for breast cancer, either as adjunct therapy or combined therapy with current anti-breast cancer drugs, with sulforaphane displaying the greatest potential.
Sanadgol N et al. • Current drug targets (2017)
Further studies with a focus on the molecular mechanisms of the protective natural compounds are needed to decrease possible side effects and to develop new medicines for MS.
Mokbel K et al. • In vivo (Athens, Greece) (2019)
Therefore, a supplement that contains these micronutrients, using the safest form and dosage should be investigated in future breast cancer chemoprevention studies and as part of standard breast ca...
Gianfredi V et al. • Nutrition and cancer (2017)
We here systematically review information on the effects of such bioactive dietary compounds on human breast cancer cell lines, and explore the mechanisms underlying those effects with a view to their potential therapeutic application.
Gianfredi V et al. • Journal of nutrigenetics and nutrigenomics (2017)
The findings suggest beneficial effects of dietary bioactive compounds such as SFN and EGCG and their effect on BC cells by restoring estrogen receptor gene expression, modulating epigenetic changes and events, and interfering with tumor growth rate.
Koushki D et al. • The journal of spinal cord medicine (2015)
IL-10 has a strong effect in the induction of neuroprotection and neurorecovery after SCI by multiple pathways.
Conzatti A et al. • Nutricion hospitalaria (2014)
Although being relevant, the evidence for the use of broccoli, GRA and SFN in humans are limited; thus, further intervention studies are needed to evaluate outcomes more consistently and reach better grounded conclusions.