1Meta-Analysis2021
Al-Jeabory M, Gasecka A, Wieczorek W, Mayer-Szary J, Jaguszewski MJ, Szarpak L · Am J Emerg Med (2021)
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1,001 peer-reviewed studies
What the evidence says
Most Tranexamic Acid (topical) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2014–2026 with a typical study size of 50 participants.
Based on 992 studies · 376 meta-analyses · 552 RCTs · 50 total participants
Confidence
High confidenceBy outcome
9 more outcomes with fewer studies not shown.
747 studies in the last 5 years · Latest meta-analysis: 2026
Al-Jeabory M, Gasecka A, Wieczorek W, Mayer-Szary J, Jaguszewski MJ, Szarpak L · Am J Emerg Med (2021)
Twum-Barimah E, Abdelgadir I, Gordon M, Akobeng AK · Aliment Pharmacol Ther (2020)
Lin YC, Wang TH, Kang YN, Chiu HH · Am J Emerg Med (2025)
Liu X, Ma Z, An J, Luo Z · PLoS One (2025)
Allen G · AORN J (2021)
Tan TK, Gopal Subramaniam A, Hau R · Eur J Orthop Surg Traumatol (2023)
Zou ZY, He LX, Yao YT · Medicine (Baltimore) (2022)
Kristjansen KA, Djebbara-Bozo N, Nanthan KR, Bønnelykke-Behrndtz ML · J Cancer Res Clin Oncol (2025)
Abu-Zaid A, Baradwan S, Albouq B, Ghazi A, Khadawardi K, Bukhari IA · Eur J Obstet Gynecol Reprod Biol (2023)
Huang L, Li P, Gu X, Zhao R, Ma X, Wei X · Asian J Surg (2022)
Assis IC, Govêia CS, Miranda DB, Ferreira RS, Riccio LGC · Braz J Anesthesiol (2023)
Kang H, Hwang SH · Braz J Otorhinolaryngol (2020)
Bright AJ, Akhter MF, Gunturi AS, Patel R, Grande P, Yesantharao PS · J Plast Reconstr Aesthet Surg (2026)
Al-Dardery NM, Abdelwahab OA, Abouzid M, Albakri K, Elkhadragy A, Katamesh BE · BMC Pregnancy Childbirth (2023)
Weng N, Gou Y, Kuang F · Asian J Surg (2023)
Yin Y, Jiang J, Zou C, Huang S, He S, Kenmegne GR · Medicine (Baltimore) (2024)
Zhang Y, Lang B, Zhao G, Wang F · J Orthop Surg Res (2020)
Fung E, Montalmant KE, Roth JM, Godek M, Li JH, Yu BZ · Aesthetic Plast Surg (2025)
Shi B, Xie W, Kai J, Li L, Sun L · BMC Musculoskelet Disord (2024)
Xiong Z, Wu K, Zhang J, Leng D, Yu Z, Zhang C · Biomed Res Int (2020)