18 peer-reviewed studies · Evidence score: 7/10
Shinjyo N et al. • Journal of evidence-based integrative medicine (2020)
However, due to the presence of multiple active constituents and relatively unstable nature of some of the active constituents, it may be necessary to revise the quality control processes, including standardization methods and shelf life.
Shinjyo N et al. • Sleep Medicine Reviews (2020)
Valerian showed a statistically significant but clinically modest improvement in subjective sleep quality across pooled RCTs.
Aldekhail NM et al. • Alternative therapies in health and medicine (2025)
Research must address herb-drug interactions, long-term effects, and biomarkers for personalized treatment. autism spectrum disorder, herbal medicines, narrative review, doses recommendation, therapeutic effects, side effects.
Crawford C et al. • Journal of alternative and complementary medicine (New York, N.Y.) (2021)
Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.
Kelber O et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2014)
In conclusion the two guidelines on genotoxicity provide a practically applicable concept.
Zabłocka-Słowińska K et al. • Psychiatria polska (2013)
However this area of science should be verified constantly due to growing number of new products registered as a supplements--often with complex composition.
Nunes A et al. • Acta medica portuguesa (2011)
Valerian root is well tolerated and safe, with infrequent and benign side effects (SOR A).
Fernández-San-Martín MI et al. • Sleep Medicine Reviews (2010)
Evidence suggests valerian might improve sleep quality with minimal side effects.
Hassani S et al. • Psychopharmacology (2015)
We concluded that, based on this study, the cognitive state of patients in the valerian group was better than that in the placebo group after CABG; therefore, it seems that the use of V. officinalis root extract may prevent early postoperative cognitive dysfunction after on-pump CABG surgery.
Roh D et al. • Phytotherapy research : PTR (2019)
Further EEG studies are needed to confirm VRE's neurophysiological effects.
Bruni O et al. • Phytotherapy Research (2021)
Valerian root extract did not impair psychomotor performance or driving ability, supporting its safety advantage over benzodiazepines for sleep.
Zare Elmi HK et al. • Chinese journal of integrative medicine (2021)
The consumption of oral valerian root extract over 30 nights could significantly improve the patients' sleep quality safely after CABG surgery.
Pakseresht S et al. • Journal of complementary & integrative medicine (2011)
The results suggest that Valeriana Officinalis L. has some antiobsessive and compulsive effects.
Ross SM • Holistic nursing practice (2015)
This rct examined the effects of Lemon Balm.
Trompetter I et al. • Wiener medizinische Wochenschrift (1946) (2013)
John's Wort herb, valerian root, and passionflower herb.
Melzer J et al. • Phytotherapy research : PTR (2009)
In total 9 non-serious adverse events were documented but the distribution did not differ significantly between the treatment groups.This herbal preparation (Ze185) showed to be an efficacious and safe short-term treatment in patients with somatoform disorders.
Leathwood PD et al. • Pharmacology Biochemistry and Behavior (1982)
Valerian significantly improved subjective assessments of sleep quality.
Unknown authors • Prescrire international (2005)
It is best to avoid high-titre alcoholic extracts and powdered valerian root, and to select aqueous extracts and low-titre hydro-alcoholic preparations.