40 peer-reviewed studies · Evidence score: 8.5/10
Hemilä H, Chalker E • BMC Public Health (2023)
Vitamin C consistently reduces the severity of the common cold across multiple trials.
Martimbianco ALC et al. • Journal of critical care (2022)
Further RCTs with higher methodological quality, an increased number of participants and assessing clinically relevant outcomes are needed to provide better decision-making guidance.
Muhammad M et al. • Advances in respiratory medicine (2022)
Given its low cost and minimal adverse effects, we strongly encourage further large, randomized trials to establish vitamin C as a standard of care in sepsis management.
Li T et al. • The American journal of emergency medicine (2021)
Based on current RCTs, our work indicated that mono-intravenous vitamin C therapy may reduce short-term mortality of sepsis patients, and it may protect organ functions.
Mason SA et al. • Diabetes care (2021)
While evidence from short-term studies suggests that vitamin C supplementation may improve glycemic control and BP in people with type 2 diabetes, vitamin C supplementation cannot currently be recommended as a therapy until larger, long-term, and high-quality trials confirm these findings.
Rawat D et al. • Nutrients (2022)
High-dose vitamin C may reduce mortality and ICU length of stay in critically ill patients.
Padhani ZA et al. • The Cochrane database of systematic reviews (2020)
Due to the small number of included studies and very low quality of the existing evidence, we are uncertain of the effect of vitamin C supplementation for the prevention and treatment of pneumonia.
Rumbold A et al. • The Cochrane database of systematic reviews (2015)
The data do not support routine vitamin C supplementation alone or in combination with other supplements for the prevention of fetal or neonatal death, poor fetal growth, preterm birth or pre-eclampsia.
Rawat D et al. • Diabetes & metabolic syndrome (2021)
No significant benefit noted with vitamin C administration in COVID-19.
Langlois PL et al. • JPEN. Journal of parenteral and enteral nutrition (2019)
A moderately large treatment effect may exist, but further studies, particularly of monotherapy administration, are warranted.
Shi R et al. • Clinical cardiology (2018)
Use of vitamin C alone and as adjunct to other therapy can prevent POAF in patients undergoing cardiac surgery and should be recommended for patients receiving cardiac surgery for prevention of POAF.
Hemilä H, Chalker E • Cochrane Database of Systematic Reviews (2013)
Regular supplementation had a modest but consistent effect in reducing the duration of common cold symptoms.
Zhong J et al. • Food & function (2024)
Plasma vitamin C has a significant reduction effect on the incidence of gastric cancer only, but additional large-scale clinical studies are needed to determine its impact on the incidence of DSCs.
Calder PC et al. • Nutrients (2025)
However, further research is required to conclusively establish its effects on immune health.
Bailey AJM et al. • Journal of the American Academy of Dermatology (2022)
Microneedling is useful adjuvant to topical therapies for the treatment of melasma.
Bayu P et al. • PloS one (2024)
This study suggests the potential ability of vitamin C and E in alleviating pain symptoms experienced by individuals with endometriosis.
Yong S et al. • Medicine (2024)
This study comprehensively and systematically evaluated IVVC supplementation in the critically ill through a meta-analysis of RCT.
Ranjbar Moghaddam M et al. • International journal of orthopaedic and trauma nursing (2024)
The results of our study showed the positive effect of VC supplementation in reducing the prevalence of CRPS-I after limb surgery.
Kow CS et al. • Inflammopharmacology (2023)
Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19.
Wen C et al. • International journal of clinical practice (2023)
More high-quality, multicenter RCTs are needed to provide more substantial evidence on the efficacy and safety of IV vitamin C for sepsis.