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Head-to-head evidence comparison — which supplement is right for you?
Arginine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
11 of 19 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
7 of 8 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Arginine and Black Pepper Extract have evidence — compare verdict strength side-by-side.
3-6g daily
30-60 minutes before exercise, Divided doses throughout the day for cardiovascular benefits
L-Arginine powder or capsules
5-20mg piperine daily
With the supplements you want to enhance, With meals containing fat
BioPerine (95% piperine standardized extract)
30-60 minutes
During exercise
2-4 weeks
Immediate
Immediate
Immediate
Nutritional interventions for preventing and treating pressure ulcers
The Cochrane database of systematic reviews (2024) · Meta analysis · n=7920
Compared to standard diet, protein supplements may result in little to no difference in pressure ulcer incidence (protein 21 per 1000, standard diet 28 per 1000; RR 0.75, 95% CI 0.49 to 1.14; 4 studies, 4264 participants; low-certainty evidence).
Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis
Nutrients (2023) · Meta analysis · n=2841
Glutamine was superior in decreasing tumor necrosis factor-α (MD -25.2; 95% CrI [-32.62, -17.95]), whereas combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85]).
Nutritional interventions for treating foot ulcers in people with diabetes
The Cochrane database of systematic reviews (2020) · Meta analysis · n=629
It is also uncertain whether arginine, glutamine and β-hydroxy-β-methylbutyrate supplement increases the proportion of ulcers healed at 16 weeks compared with placebo (RR 1.09, 95% CI 0.85 to 1.40).
Does curcumin improve liver enzymes levels in nonalcoholic fatty liver disease? A systematic review, meta-analysis, and meta-regression
Phytotherapy research : PTR (2024) · Meta analysis · n=835
Subgroup analysis revealed that adding piperine to curcumin did not benefit aminotransferase levels in NAFLD patients.
Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials
Nutrition reviews (2025) · Meta analysis · n=905
Curcumin supplementation significantly reduced ALT (weighted mean difference [WMD], -4.10, 95%CI, -7.16 to -1.04) and AST (WMD, -3.27; 95%CI, -5.16 to -1.39), but not ALP (WMD, -0.49; 95%CI, -1.79 to 0.82).
A systematic review and meta-analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders
Phytotherapy research : PTR (2023) · Meta analysis
The combined results by the random-effects model demonstrated that curcumin plus piperine significantly decreased total cholesterol and LDL-C in patients suffering from metabolic syndrome.
Based on meta-analysis showing mean reductions of 5.39 mmHg systolic and 2.66 mmHg diastolic. Effects are modest and may not be clinically significant for all individuals. GI side effects increase notably above 6g.
Evidence from multiple studies showing piperine enhances absorption of co-administered compounds like curcumin. Most studies used 5-20mg range. Conservative effectiveness estimates due to variable study designs and co-administration contexts. May also enhance drug absorption leading to potential interactions.
AI-estimated from published studies. Interpret as directional guidance.
Arginine has a higher evidence score (9/10 vs 7.5/10) and wins in 2 of 3 categories.
For reduce inflammation, Arginine has a higher relevance score (70 vs 40).
No known interactions between Arginine and Black Pepper Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.