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Head-to-head evidence comparison — which supplement is right for you?
Arginine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
11 of 19 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
5 of 5 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Arginine and Butyrate have evidence — compare verdict strength side-by-side.
3-6g daily
30-60 minutes before exercise, Divided doses throughout the day for cardiovascular benefits
L-Arginine powder or capsules
300-600mg sodium/calcium butyrate, 2-3x daily
With meals, Spread throughout day
Enteric-coated sodium or calcium butyrate
30-60 minutes
During exercise
2-4 weeks
Immediate
2-4 weeks
4-8 weeks
Nutritional interventions for preventing and treating pressure ulcers
The Cochrane database of systematic reviews (2024) · Meta analysis · n=7920
Compared to standard diet, protein supplements may result in little to no difference in pressure ulcer incidence (protein 21 per 1000, standard diet 28 per 1000; RR 0.75, 95% CI 0.49 to 1.14; 4 studies, 4264 participants; low-certainty evidence).
Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis
Nutrients (2023) · Meta analysis · n=2841
Glutamine was superior in decreasing tumor necrosis factor-α (MD -25.2; 95% CrI [-32.62, -17.95]), whereas combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85]).
Nutritional interventions for treating foot ulcers in people with diabetes
The Cochrane database of systematic reviews (2020) · Meta analysis · n=629
It is also uncertain whether arginine, glutamine and β-hydroxy-β-methylbutyrate supplement increases the proportion of ulcers healed at 16 weeks compared with placebo (RR 1.09, 95% CI 0.85 to 1.40).
Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis
JAMA psychiatry (2021) · Meta analysis · n=1519
There was a small decrease in phylogenetic diversity (SMD = -0.24; 95% CI, -0.47 to -0.001) and no significant differences in Shannon and Simpson indices.
Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis
The American journal of clinical nutrition (2018) · Meta analysis · n=2099
Dietary fiber intervention, particularly involving fructans and galacto-oligosaccharides, leads to higher fecal abundance of Bifidobacterium and Lactobacillus spp. but does not affect α-diversity.
Efficacy of a postbiotic and its components in promoting colonic transit and alleviating chronic constipation in humans and mice
Cell reports. Medicine (2025) · Animal · n=110
A randomized, double-blind, placebo-controlled crossover trial involving 110 adults with chronic constipation (Rome IV criteria) demonstrates that a 3-week Probio-Eco intervention significantly improves constipation symptoms, stool straining, and worry scores.
Based on meta-analysis showing mean reductions of 5.39 mmHg systolic and 2.66 mmHg diastolic. Effects are modest and may not be clinically significant for all individuals. GI side effects increase notably above 6g.
Based on SCFA studies showing 44% butyrate increase with Mediterranean diet intervention and gut barrier integrity improvements. Conservative estimates due to limited direct butyrate supplementation RCTs. Effectiveness varies significantly by form - tributyrin forms may show higher bioavailability.
AI-estimated from published studies. Interpret as directional guidance.
Arginine has a higher evidence score (9/10 vs 8.5/10) and wins in 2 of 3 categories.
For reduce inflammation, Butyrate has a higher relevance score (95 vs 70).
No known interactions between Arginine and Butyrate have been documented in our database. However, always consult a healthcare provider before combining supplements.