Azelaic Acid vs Thiamidol

Throughout

4-15 weeks

8-24 weeks

4-12 weeks

immediate

12 weeks

2-3 weeks

3 weeks

Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies.

J Am Acad Dermatol (2003) · Rct · n=664

Two double-blind, vehicle-controlled phase III RCTs (664 patients total) of 15% azelaic acid gel twice daily for moderate papulopustular rosacea

A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial.

Arch Dermatol (2003) · Rct · n=251

Multicenter, double-blind, randomized head-to-head trial in 251 patients with moderate papulopustular rosacea over 15 weeks

Interventions for rosacea.

Cochrane Database Syst Rev (2015) · Systematic review

Cochrane review of 106 RCTs (13,631 participants) of rosacea treatments with GRADE quality assessment

Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase

J Invest Dermatol (2018) · In vitro

The discovery paper, and the reason this ingredient exists: most tyrosinase inhibitors were screened against MUSHROOM tyrosinase, which is why so many lack clinical effect.

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial

J Eur Acad Dermatol Venereol (2021) · Rct · n=50

The comparison that matters: head to head against 4% hydroquinone, the prescription-strength benchmark.

Thiamidol in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase

J Dermatol (2021) · Rct · n=48

The study the abstract calls the FIRST 24-week randomized, double-blind, vehicle-controlled assessment of thiamidol in moderate-to-severe melasma, with a subsequent regression phase.