Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
B. infantis 35624 vs Lactase: Lactase has the stronger overall evidence (5.5 vs 5/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Lactase wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both B. infantis 35624 and Lactase have evidence — compare verdict strength side-by-side.
1 x 10^8 CFU (100 million) daily — the dose that won the only head-to-head dose comparison; 1 x 10^10 CFU also beat placebo in a separate trial, so higher doses are not ruled out
Any time of day
Freeze-dried capsule standardized to 35624 at 1 x 10^8 CFU
Taken per lactose-containing meal, not as a daily dose. Trials gave 3,000 to 11,250 units of lactase (mostly FCC units) immediately before or with a single dairy or lactose challenge. One 2022 trial used 4,662 FCC units and describes 4,500 FCC units as the amount in the EU-approved health claim. More lactose needs more enzyme: 50 g of lactose given in water overwhelmed about 6,000 units in one trial. Products differ, so dose by the enzyme units on the label rather than by tablet count.
With meals
Lactase tablets, capsules or chewables labelled in FCC units, taken with dairy
4 weeks
4 weeks
n/a
n/a
Hours (same meal)
Hours (same meal)
Hours (same meal)
Hours (same meal)
Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome.
Am J Gastroenterol (2006) · Rct · n=362
1 x 10^8 CFU significantly superior to placebo AND to all other doses for the primary endpoint of abdominal pain
Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.
Gastroenterology (2005) · Rct · n=77
Beat placebo on composite score and on abdominal pain, bloating/distention and bowel-movement difficulty for most treatment weeks
Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis.
Curr Med Res Opin (2017) · Meta analysis
Single-strain 35624 had no effect on abdominal pain, bloating/distention, or bowel-habit satisfaction
Systematic review: effective management strategies for lactose intolerance.
Annals of Internal Medicine (2010) · Systematic review
36 randomised trials met the inclusion criteria, 26 of them on lactase- or lactose-hydrolysed milk supplements, lactose-reduced milk, or tolerable doses of lactose.
Effect of lactase supplementation on infant colic: Systematic review of randomized controlled trials.
Journal of Pediatric Gastroenterology and Nutrition (2024) · Meta analysis · n=391
Five randomised trials with 391 infants under 6 months old with colic were included.
The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial.
European Review for Medical and Pharmacological Sciences (2010) · Rct · n=60
60 lactose-intolerant patients were randomised to tilactase taken 15 minutes before a lactose breath test, placebo, or Lactobacillus reuteri twice daily for 10 days beforehand (20 per group).
Lactase has a higher evidence score (5.5/10 vs 5/10) and wins in 2 of 3 categories.
For improve digestion, B. infantis 35624 has a higher relevance score (58 vs 45).
No known interactions between B. infantis 35624 and Lactase have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.