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Head-to-head evidence comparison — which supplement is right for you?
B. longum 1714 vs L. helveticus R0052 + B. longum R0175: they're closely matched on evidence (3 vs 3/10); they're alternatives for support mood — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
B. longum 1714 and L. helveticus R0052 + B. longum R0175 are closely matched across evidence, studies, and safety.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both B. longum 1714 and L. helveticus R0052 + B. longum R0175 have evidence — compare verdict strength side-by-side.
1 x 10^9 to 1 x 10^10 CFU daily — the two trials that state a dose used 1 x 10^10 CFU/day (depression) and a minimum of 1 x 10^9 CFU/day (pregnancy). Neither found a benefit on its primary endpoint, so this is the dose range that has been tested, not a dose shown to work.
any
Freeze-dried capsule or sachet standardized to B. longum 1714
3 x 10^9 CFU daily of the fixed combination (L. helveticus R0052 plus B. longum R0175) — the dose used in the founding trial, the dancer trial and the open-label MDD study. No dose-comparison study exists.
any
Fixed two-strain sachet or capsule: L. helveticus R0052 plus B. longum R0175 at 3 x 10^9 CFU
No interaction. Both have failed their most rigorous tests: 1714 found no effect on the primary endpoint in 168 adults with mild-to-moderate depression, and the R0052 + R0175 combination was null on every pre-specified outcome in 135 healthy adults.
Listed for disambiguation rather than for stacking — no trial has combined them.
4 weeks
8 weeks
n/a
n/a
8 weeks
3 weeks
n/a
n/a
Effects of Bifidobacterium longum 1714 on low mood and related symptoms: A randomized, double-blind, placebo-controlled trial.
Exp Clin Psychopharmacol (2026) · Rct · n=168
PRIMARY ENDPOINT MISSED: BDI-II change vs placebo was -0.303 (95% CI -1.957 to 1.35, p=.718) at week 4 and -1.432 (95% CI -3.30 to 0.44, p=.132) at week 8
Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial.
Sci Rep (2024) · Rct · n=89
PRIMARY ENDPOINT MISSED: PSQI global score improved in both groups, with no significant advantage for the strain
Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers.
Transl Psychiatry (2016) · Pilot · n=22
PubMed classifies this as a Controlled Clinical Trial, NOT a Randomized Controlled Trial
Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial.
Clin Nutr (2019) · Rct · n=110
BDI score fell 17.39 to 9.1 on the probiotic vs 18.18 to 15.55 on placebo and 19.72 to 14.14 on prebiotic (p=0.042)
Psychobiotic Effects on Anxiety Are Modulated by Lifestyle Behaviors: A Randomized Placebo-Controlled Trial on Healthy Adults.
Nutrients (2023) · Rct · n=135
NULL on the whole sample: 'no significant effects of probiotic intake in whole sample outcomes'
Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects.
Br J Nutr (2011) · Rct
The abstract states NO sample size, NO effect sizes and NO confidence intervals for the human trial
Both B. longum 1714 and L. helveticus R0052 + B. longum R0175 are closely matched — the best choice depends on your specific health goals.
For support mood, L. helveticus R0052 + B. longum R0175 has a higher relevance score (34 vs 20).
No interaction. Both have failed their most rigorous tests: 1714 found no effect on the primary endpoint in 168 adults with mild-to-moderate depression, and the R0052 + R0175 combination was null on every pre-specified outcome in 135 healthy adults. Listed for disambiguation rather than for stacking — no trial has combined them. Consult a healthcare provider for personalized advice.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.