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Head-to-head evidence comparison — which supplement is right for you?
Lactotripeptides wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
150 mg/day of standardized αs1-casein hydrolysate (Lactium), taken once daily; acute studies have used ~200 mg
evening
αs1-Casein hydrolysate standardized to α-casozepine (Lactium)
~3-5 mg combined VPP + IPP per day (the dose used in most positive fermented-milk trials)
any
Fermented milk (Lactobacillus helveticus)
2-4 weeks
Within hours of a dose
2-4 weeks
N/A
4-8 weeks
4-8 weeks
Throughout use
N/A
Efficacy of alphas1-casein hydrolysate on stress-related symptoms in women.
Eur J Clin Nutr (2007) · Rct · n=63
Double-blind, randomized, crossover, placebo-controlled trial in 63 women with stress-related symptoms (anxiety, sleep problems, fatigue)
Effects of a tryptic hydrolysate from bovine milk alphaS1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations.
Eur J Nutr (2005) · Rct
Double-blind randomized study in healthy volunteers given 200 mg αs1-casein hydrolysate vs skimmed-milk-powder placebo
A Double-Blind, Randomized, Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-s1 Casein Hydrolysate on Sleep Disturbance.
Nutrients (2019) · Rct · n=48
Double-blind randomized crossover trial in 48 community-based Koreans with mild-to-moderate sleep disturbance; ACH (Lactium) vs placebo for 4 weeks each
Casein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials.
Nutrients (2015) · Meta analysis
Comprehensive meta-analysis of 30 RCTs (33 data sets) of lactotripeptides on blood pressure
Lactotripeptides intake and blood pressure management: a meta-analysis of randomised controlled clinical trials.
Nutr Metab Cardiovasc Dis (2013) · Meta analysis
Meta-analysis of 24 studies (28 trials, 1919 subjects)
Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials.
J Hum Hypertens (2011) · Meta analysis
Meta-analysis of 18 placebo-controlled trials of VPP/IPP as functional foods
Lactotripeptides has a higher evidence score (4.5/10 vs 4/10) and wins in 2 of 3 categories.
No known interactions between Casein Hydrolysate and Lactotripeptides have been documented in our database. However, always consult a healthcare provider before combining supplements.