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Head-to-head evidence comparison — which supplement is right for you?
Folic Acid vs Sage: Folic Acid has the stronger overall evidence (8 vs 6/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Folic Acid wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
400 mcg/day for anyone planning or capable of pregnancy (USPSTF: 400-800 mcg); adult RDA 400 mcg DFE/day, 600 mcg DFE in pregnancy, 500 mcg DFE in lactation (IOM)
any
Folic acid (pteroylmonoglutamic acid)
300–600 mg standardized extract daily
With breakfast, With dinner (split dosing)
Standardized extract (300–600 mg, 2.5% rosmarinic acid)
and 4 more not shown
Periconceptional
Weeks
Weeks to months
4–8 weeks
4–8 weeks
4–8 weeks
8–12 weeks
Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.
N Engl J Med (1992) · Rct
Randomised trial of periconceptional vitamin supplementation for prevention of a FIRST neural tube defect (PubMed publication types: Randomized Controlled Trial, Clinical Trial)
Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group.
Lancet (1991) · Rct
Randomised, multicentre trial of periconceptional folic acid for prevention of RECURRENT neural tube defects (PubMed publication types: Randomized Controlled Trial, Multicenter Study, Comparative Study)
Effects and safety of periconceptional oral folate supplementation for preventing birth defects.
Cochrane Database Syst Rev (2015) · Meta analysis
Cochrane Database of Systematic Reviews CD007950, third edition (PubMed publication types: Meta-Analysis, Systematic Review)
Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease.
CNS Neuroscience & Therapeutics (2014) · Systematic review
Multiple clinical trials demonstrated improvements in memory and attention in healthy young adults following acute and chronic Salvia officinalis or Salvia lavandulaefolia administration.
Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.
BMC Complementary Medicine and Therapies (2025) · Rct · n=60
Women with PCOS receiving Salvia officinalis extract showed significant reductions in total cholesterol, LDL cholesterol, and triglycerides compared to the placebo group.
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
J Clin Pharm Ther (2003) · Rct · n=42
Significant improvement in ADAS-cog and CDR-SB scores vs placebo (P<0.003)
Based on multiple RCTs showing improvements in word recall, working memory, and attention. Effects varied by specific cognitive domain and population. Most studies used standardized extracts.
AI-estimated from published studies. Interpret as directional guidance.
Folic Acid has a higher evidence score (8/10 vs 6/10) and wins in 2 of 3 categories.
No known interactions between Folic Acid and Sage have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.