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Head-to-head evidence comparison — which supplement is right for you?
Kojic Acid vs Thiamidol: Thiamidol has the stronger overall evidence (6.5 vs 6/10); they're alternatives for even skin tone — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Thiamidol wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Kojic Acid and Thiamidol have evidence — compare verdict strength side-by-side.
Topical cosmetic only. Kojic acid is typically used at roughly 1-2% in leave-on serums or creams (or as the more stable kojic acid dipalmitate), applied to areas of hyperpigmentation once or twice daily, often alongside other brighteners and daily sunscreen. There is no oral, injectable, or systemic dose — it is not ingested. This library does not provide an ingestion protocol.
any
Leave-on topical serum or cream (≈1-2% kojic acid, or kojic acid dipalmitate)
Apply a thiamidol-containing serum or cream at 0.1-0.2% twice daily to the affected area, alongside daily broad-spectrum SPF 30 or higher. Continue 12-24 weeks.
morning, evening
Thiamidol 0.2% serum
Throughout
8-12 weeks
Throughout
1-12 months
immediate
12 weeks
2-3 weeks
3 weeks
Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid.
Dermatol Surg (1999) · Rct · n=40
Split-face randomized design in 40 women with epidermal melasma: 2% kojic acid added to a 10% glycolic acid + 2% hydroquinone base vs the base alone
Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta-analysis.
J Cosmet Dermatol (2023) · Meta analysis
Pooled 45 efficacy studies (2359 patients) of topical melasma treatments using MASI standardised mean differences
Kojic Acid vis-a-vis its Combinations with Hydroquinone and Betamethasone Valerate in Melasma: A Randomized, Single Blind, Comparative Study.
Indian J Dermatol (2013) · Rct · n=80
80 melasma patients randomized over 12 weeks to kojic acid 1% alone, kojic acid + hydroquinone 2%, kojic acid + betamethasone, or all three (MASI-assessed)
Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase
J Invest Dermatol (2018) · In vitro
The discovery paper, and the reason this ingredient exists: most tyrosinase inhibitors were screened against MUSHROOM tyrosinase, which is why so many lack clinical effect.
Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial
J Eur Acad Dermatol Venereol (2021) · Rct · n=50
The comparison that matters: head to head against 4% hydroquinone, the prescription-strength benchmark.
Thiamidol in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase
J Dermatol (2021) · Rct · n=48
The study the abstract calls the FIRST 24-week randomized, double-blind, vehicle-controlled assessment of thiamidol in moderate-to-severe melasma, with a subsequent regression phase.
Thiamidol has a higher evidence score (6.5/10 vs 6/10) and wins in 3 of 3 categories.
For even skin tone, Thiamidol has a higher relevance score (88 vs 70).
No known interactions between Kojic Acid and Thiamidol have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.