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Head-to-head evidence comparison — which supplement is right for you?
L-Citrulline vs Yohimbe: L-Citrulline has the stronger overall evidence (6 vs 5/10); they're alternatives for libido & male vitality — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
L-Citrulline wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both L-Citrulline and Yohimbe have evidence — compare verdict strength side-by-side.
3-6g (or 6-8g citrulline malate)
30-60 minutes before exercise, Or split doses throughout day
L-Citrulline powder (pure form)
Standardized yohimbine ~5-10mg (or ~0.2mg/kg) up to 1-2x daily; start at the lowest dose. Raw yohimbe bark is discouraged due to unpredictable content. The one cited trial that states a dose gave a single 10 mg dose.
Morning
Standardized yohimbine HCl (known dose)
and 2 more not shown
1-2 weeks
24-48 hours post-exercise
30-60 minutes
With doses >10g
2-8 weeks
Acute
Acute
Throughout use
Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis
Nutrients (2023) · Meta analysis
We observed no difference between pre- vs. post-exercise for oxidative stress (subtotal = -0.21 [CI: -0.56, 0.14], p = 0.24, and heterogeneity = 0%.
Effects of Citrulline or Watermelon Supplementation on Body Composition: A Systematic Review and Dose-Response Meta-Analysis
Nutrients (2025) · Meta analysis
Overall, CIT supplementation had no substantial effects on body mass index (BMI), body weight, fat mass (FM), waist circumference (WC), body fat percentage (BFP), and fat-free mass (FFM).
Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials
Journal of the International Society of Sports Nutrition (2021) · Meta analysis
No effect on exercise performance following consumption of foods rich in L-citrulline was identified (SMD=-0.03, p=0.24).
Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.
The Journal of urology (1998) · Meta analysis
Yohimbine significantly more effective than placebo for ED
Erectile dysfunction.
BMJ clinical evidence (2011) · Review
Yohimbine has modest ED efficacy
Pharmacological interventions in primary or secondary male anorgasmia: A systematic review.
Actas urologicas espanolas (2025) · Systematic review
Yohimbine among agents assessed for anorgasmia
L-Citrulline has a higher evidence score (6/10 vs 5/10) and wins in 3 of 3 categories.
For libido & male vitality, L-Citrulline has a higher relevance score (80 vs 68).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.