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Head-to-head evidence comparison — which supplement is right for you?
Pumpkin Seed Oil vs Rye Pollen Extract: Rye Pollen Extract has the stronger overall evidence (4.8 vs 4.5/10); they're alternatives for prostate health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Rye Pollen Extract wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Pumpkin Seed Oil and Rye Pollen Extract have evidence — compare verdict strength side-by-side.
1000–2000 mg daily (oral capsule) or 3 g/day for cardiovascular benefit
With meals (lunch or dinner), Split dose morning and evening with food
Cold-pressed softgel capsule
2 capsules/tablets three times daily (every 8 hours), or 375-750 mg twice daily
Three divided doses per day, roughly every 8 hours, With or without food — no trial specified a meal requirement
Cernilton / Cernitin standardized rye-grass pollen extract
4-12 weeks
8-12 weeks
6 weeks
8-12 weeks
12-24 weeks
12-24 weeks
6-12 weeks
6-12 weeks
Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss: A Systematic Review.
JAMA Dermatology (2023) · Systematic review
30 articles were included comprising 17 RCTs, 11 clinical studies, and 2 case series in individuals without known nutritional deficiency
Pumpkin seed oil (Cucurbita pepo) versus tamsulosin for benign prostatic hyperplasia symptom relief: a single-blind randomized clinical trial.
BMC Urology (2021) · Rct · n=73
Both tamsulosin and pumpkin seed oil (360 mg twice daily) produced significant decreases in IPSS and improvements in quality of life over 3 months
The effects of pumpkin seed oil supplementation on arterial hemodynamics, stiffness and cardiac autonomic function in postmenopausal women.
Complementary Therapies in Clinical Practice (2019) · Rct · n=23
Augmentation index (AIx), brachial and central systolic blood pressure significantly decreased following PSO (3 g/day for 6 weeks) but not placebo (P<0.05)
Cernilton for benign prostatic hyperplasia
Cochrane Database of Systematic Reviews (2000) · Systematic review · n=444
444 men were enrolled in 2 placebo-controlled and 2 comparative trials lasting from 12 to 24 weeks; three used a double-blind method although treatment allocation concealment was unclear in all.
A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
European Urology (2009) · Rct · n=139
139 men with NIH category IIIA CP/CPPS were randomised to pollen extract (n=70) or placebo (n=69), dosed as two capsules every 8 hours for 12 weeks.
A systematic review of Cernilton for the treatment of benign prostatic hyperplasia
BJU International (2000) · Systematic review · n=444
444 men were enrolled in two placebo-controlled and two comparative trials lasting 12-24 weeks; concealment of treatment allocation was unclear in all.
Based on RCT showing PSO 360mg twice daily improved IPSS scores but was less effective than tamsulosin. Conservative estimates given limited dose-response data and small study size (n=73).
AI-estimated from published studies. Interpret as directional guidance.
Rye Pollen Extract has a higher evidence score (4.8/10 vs 4.5/10) and wins in 3 of 3 categories.
For prostate health, Rye Pollen Extract has a higher relevance score (78 vs 75).
No known interactions between Pumpkin Seed Oil and Rye Pollen Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.