Compare Supplements

200mg

Before bed

Capsules

Prescription only — a clinician sets the dose. The doses studied for sleep are low: the placebo-controlled trials that show anything used 50 mg at bedtime (30 min before bed in the primary-insomnia study; 10 PM in the Alzheimer's study), and the systematic-review literature treats <100 mg/day as the 'low-dose' insomnia range versus ≥100 mg/day as the antidepressant range. This is entirely OFF-LABEL. The approved indication is major depressive disorder, where outpatient dosing goes up to 400 mg/day in divided doses (up to 600 mg/day in monitored inpatients).

Before bed

Immediate-release oral tablet, prescribed and dose-titrated by a clinician

• Currently taking SSRIs, SNRIs, MAOIs, or other serotonergic drugs
• Carcinoid syndrome
• Scleroderma

• SSRIs (Prozac, Zoloft, etc.)
• MAO inhibitors
• SNRIs (venlafaxine, duloxetine, etc.)

• Concurrent MAO inhibitors, or within the washout period after stopping one — risk of serotonin syndrome
• Known hypersensitivity to trazodone
• Anyone without a prescription — trazodone is a prescription antidepressant, not a supplement

• SSRIs and SNRIs (e.g. sertraline, fluoxetine, venlafaxine)
• MAO inhibitors
• Serotonergic supplements — 5-HTP, St John's wort, SAM-e, L-tryptophan