Compare Supplements

Topical use. Adapalene 0.1% (OTC) or 0.3% (prescription) gel/cream is applied as a thin layer to the whole affected area once daily, usually at night, starting every other day and building to nightly as tolerated. Full benefit takes ~8-12 weeks. There is no oral or systemic dose — it is not ingested. It is most effective combined with benzoyl peroxide. This library does not provide an ingestion protocol.

Evening

Adapalene 0.1% gel/cream (OTC), applied nightly to the whole area

Topical OTC use. Leave-on and wash-off acne products contain 0.5-2% salicylic acid, applied to affected areas once or twice daily and built up as tolerated; professional peels (20-30%) are applied in-office. There is no oral or systemic dose in this context — it is not ingested (and large-area/high-concentration use can cause systemic salicylate absorption, so follow label limits). This library does not provide an ingestion protocol.

Any time

Leave-on or wash-off acne product (0.5-2% salicylic acid)

• For topical (skin) use only — not for ingestion, not for injection
• Pregnancy and breastfeeding — retinoids are generally avoided as a precaution
• Known allergy/sensitivity to adapalene or formulation excipients

• Other irritating actives (other retinoids, AHAs/BHAs)
• Benzoyl peroxide

• For topical (skin) use only — not for ingestion, not for injection
• Known allergy/sensitivity to salicylates or aspirin
• Do not apply to large body-surface areas at high concentration (risk of systemic salicylate absorption / salicylism)

• Other leave-on actives (retinoids, AHAs, benzoyl peroxide)
• Oral salicylates / anticoagulants (only if extensive high-strength use)