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Historically Olmifon was dosed around 600–1200 mg/day (in divided doses, earlier in the day) — roughly 3–4× a modafinil dose because of incomplete hepatic conversion. There is no approved or standardized regimen today; it is an unapproved grey-market chemical and not a clinician-supervised drug.

Morning

Oral capsule/powder (grey-market; no approved product)

Approved dosing is 200 mg once daily in the morning for narcolepsy and OSA, or 200 mg taken ~1 hour before the start of a night shift for shift-work sleep disorder. A prescription drug; off-label cognitive use is not an approved or standardized regimen.

Morning

Oral tablet (modafinil)

• Liver disease or elevated baseline liver enzymes (hepatic conversion step)
• Concurrent hepatotoxic drugs or heavy alcohol use
• Uncontrolled hypertension or arrhythmia (use with caution)

• Hepatotoxic drugs / alcohol
• Hormonal contraceptives
• Other stimulants / MAO inhibitors

• Prior hypersensitivity or serious skin reaction to modafinil/armodafinil
• History of left ventricular hypertrophy or mitral valve prolapse with prior stimulant use
• Uncontrolled hypertension or arrhythmia (use with caution)

• Hormonal contraceptives
• Warfarin / CYP2C19 substrates
• MAO inhibitors / other stimulants