Compare Supplements

Topical: apply gel as needed. Oral: ~50-100mg inner-leaf extract or ~30-50ml decolorized juice daily

Any time

Topical inner-leaf gel; decolorized inner-leaf for oral use

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Any time

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

• Oral use of aloe latex (laxative anthraquinones)
• Pregnancy (oral latex)
• Bowel obstruction or IBD flare (oral)

• Diabetes medications
• Diuretics/laxatives
• Digoxin

• Personal or family history of medullary thyroid carcinoma (MTC)
• Multiple endocrine neoplasia syndrome type 2 (MEN2)
• History of pancreatitis (use with caution / avoid)

• Oral contraceptives
• Insulin and sulfonylureas
• Oral medications generally