Compare Supplements

Side-by-side comparison of 2 supplements

Arb4.0

Alpha-Arbutin

High safety

Koj6.0

Kojic Acid

Moderate safety

Evidence

Evidence Score4/10

Studies: 6

Meta-analyses: 0

Evidence Score6/10

Studies: 7

Meta-analyses: 1

Outcome Grades

Even skin toneD

Even skin toneC

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

Topical cosmetic only. Alpha-arbutin is typically used at roughly 1-2% in leave-on serums, applied to areas of hyperpigmentation once or twice daily, usually alongside daily sunscreen and often with other brighteners. There is no oral, injectable, or systemic dose — it is not ingested. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical serum (≈1-2% alpha-arbutin)

Dosage:

Topical cosmetic only. Kojic acid is typically used at roughly 1-2% in leave-on serums or creams (or as the more stable kojic acid dipalmitate), applied to areas of hyperpigmentation once or twice daily, often alongside other brighteners and daily sunscreen. There is no oral, injectable, or systemic dose — it is not ingested. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical serum or cream (≈1-2% kojic acid, or kojic acid dipalmitate)

What you'll notice

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

🌗 Modest brightening / more even tonepositive

8-12 weeks

✅ Generally well toleratedpositive

Throughout

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

🌗 Reduced hyperpigmentation / more even tonepositive

8-12 weeks

⚠️ Modest, and mostly proven in combinationneutral

Throughout

Safety

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to arbutin or hydroquinone
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Other leave-on actives (acids, retinoids, other brighteners)

Side Effects:

Mild local irritation or rednessHydroquinone-related sensitivity (from degraded product)

Moderate safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to kojic acid
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Other leave-on actives (acids, retinoids, hydroquinone)

Side Effects:

Contact dermatitis / allergic sensitisationLocal irritation, redness, or stinging

How they work together

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