Compare Supplements

Side-by-side comparison of 2 supplements

Agp8.5

Alpha-GPC

Moderate safety

B129.0

Vitamin B12

High safety

Evidence

Evidence Score8.5/10

Studies: 22

Meta-analyses: 2

Evidence Score9/10

Studies: 63

Meta-analyses: 21

Outcome Grades

Sharpen focusB

NeuroprotectionB

Boost daily energyC

Improve memory & learningB

Sharpen focusB

NeuroprotectionB

Boost daily energyA

Improve memory & learningC

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Pooled effect-size head-to-headBeta

Direct side-by-side from the meta-analysis. Each row is an outcome where ≥2 of your selected supplements have pooled data. Best effect per row highlighted.

Outcome	Alpha-GPC	Vitamin B12
Improve memory & learning — Working Memory + better · SD-units (composite)	+0.8best weak	+0.2 weak · CI ∋ 0

Click an outcome to see the full ranked table on the goal page.

Dosage & timing

Dosage:

600mg

Best Time:

Morning · with food (preferred)

Can take on empty stomach

Form:

Alpha-GPC 50% powder or capsules

Dosage:

500-1000mcg daily for maintenance; higher for deficiency

Best Time:

Morning · with food (preferred)

Can take on empty stomach

Form:

Methylcobalamin (sublingual)

What you'll notice

🎯 Sharper Focus70%

1-2 hours

📚 Memory Support60%

2-4 weeks

💪 Power Output45%

Acute

⚡ Energy Restoration80%

2-4 weeks

🧠 Cognitive Support65%

4-8 weeks

⚡ Nerve Health70%

Weeks to months

Safety

Moderate safety

Contraindications:

History of stroke or TIA (one study raised concerns, needs more research)

Drug Interactions:

Anticholinergic drugs
Cholinergic drugs

Side Effects:

HeadacheFishy body odorGI upset

High safety

Contraindications:

Leber's hereditary optic neuropathy (may worsen)
Cobalt or cobalamin hypersensitivity

Drug Interactions:

Metformin
PPIs (proton pump inhibitors)

Side Effects:

Mild GI upsetAcne-like skin eruption (high doses)Allergic reaction (rare, usually with injection)

Works well with

complementary

stacks-well

enhances

complementary

enhances

complementary

How they work together

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Outcome

Alpha-GPC

Vitamin B12

Improve memory & learning — Working Memory

+ better · SD-units (composite)

+0.8best

weak

+0.2

weak · CI ∋ 0