Compare Supplements

Side-by-side comparison of 2 supplements

Ala7.0

Alpha Lipoic Acid

Moderate safety

Mfn4.0

Metformin

Limited safety

Evidence

Likely helps

Evidence Score7/10

Studies: 87

Meta-analyses: 21

Mostly mechanism / observational

Evidence Score4/10

Studies: 8

Meta-analyses: 1

Dosage & timing

Dosage:

600mg

Best Time:

Between meals

Can take on empty stomach

Form:

R-Alpha Lipoic Acid (R-ALA) — the natural form

Dosage:

Off-label longevity use mirrors diabetes dosing (commonly 500–1500 mg/day of extended-release with meals) under a clinician. Not an approved longevity regimen, and unnecessary in well-controlled non-diabetics without a clear rationale.

Best Time:

With meals · with food

Take with food

Form:

Extended-release tablet

What you'll notice

📊 Blood Sugar Controlpositive

4-12 weeks

🔌 Nerve Healthpositive

4-8 weeks

✨ Antioxidant Boostpositive

2-4 weeks

📉 Glycemic controlpositive

Weeks

📊 Possible mortality benefit (epidemiology)positive

Years

🏃 May blunt exercise adaptationtrade-off

Weeks of training

Safety

Moderate safety

Contraindications:

Thiamine (B1) deficiency
Excessive alcohol use
Uncontrolled Diabetes - use with caution

Drug Interactions:

Diabetes medications
Chemotherapy

Side Effects:

NauseaSkin rashHypoglycemia

Limited safety

Contraindications:

Severe renal impairment (eGFR < 30)
Acute metabolic acidosis
Conditions predisposing to lactic acidosis (severe hypoxia, decompensated heart failure)

Drug Interactions:

Iodinated contrast
Alcohol (excessive)

Side Effects:

GI upset (diarrhea, nausea)Vitamin B12 depletionLactic acidosis

Works well with

Acetyl-L-Carnitine

enhances

B-Complex

complementary

Benfotiamine

complementary

No synergies listed

How they work together

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