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One AREDS2 daily regimen, usually split into two servings: vitamin C 500 mg, vitamin E 400 IU, lutein 10 mg, zeaxanthin 2 mg, zinc 80 mg (as zinc oxide) and copper 2 mg (as cupric oxide)

With meals · with food

A product matching the AREDS2 composition exactly: vitamin C 500 mg, vitamin E 400 IU, lutein 10 mg, zeaxanthin 2 mg, zinc 80 mg, copper 2 mg

1 x 10^9 CFU (1 billion) daily taken WITH the iron-containing meal is sufficient for the iron effect — in the dual-isotope crossover trial 10^9 was significant (28.6% vs 18.5%, p<0.028) while 10^10 was NOT (29.1% vs 20.1%, p=0.080). The freeze-dried capsule and IBS trials used 1 x 10^10 CFU daily, and the pregnancy trial used 1 x 10^10 CFU twice daily (2 x 10^10 CFU/day)

With meals · with food

Freeze-dried capsule standardized to 299v (DSM 9843)

• The ORIGINAL AREDS formula (containing beta-carotene) in anyone who currently smokes or has ever smoked — beta-carotene increased lung cancer incidence in ATBC (+18%) and CARET (RR 1.28), and doubled 10-year lung cancer odds in AREDS2 itself (OR 1.82)
• Concurrent use with other beta-carotene or high-dose vitamin A supplements in smokers and former smokers
• Wilson's disease or other copper-overload states (the formula supplies 2 mg copper)

• Other zinc-containing supplements or lozenges
• Copper supplements
• Anticoagulants and antiplatelets (warfarin, DOACs, aspirin)

• Immunocompromise or immunosuppression (class-level precaution for live probiotics)
• Critical illness or indwelling central venous catheter
• Short-bowel syndrome or compromised gut barrier

• Oral iron supplements
• Systemic antibiotics