Compare Supplements

Side-by-side comparison of 2 supplements

Arl3.0

Argireline

High safety

Bak4.0

Bakuchiol

High safety

Evidence

Evidence Score3/10

Studies: 6

Meta-analyses: 0

Evidence Score4/10

Studies: 6

Meta-analyses: 0

Outcome Grades

Reduce wrinkles & fine linesD

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

Topical cosmetic only. Argireline is typically formulated at 5-10% in leave-on serums, creams, or gels and applied to the target area (e.g., crow's-feet, forehead) twice daily. There is no oral, injectable, or systemic dose — it is not ingested. Concentration and formulation drive how much actually penetrates the skin. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical cosmetic (serum, cream, or gel) at 5-10%

Dosage:

Topical cosmetic only. Bakuchiol is typically formulated around 0.5-1% in leave-on serums or creams and applied to clean skin once or twice daily. Unlike retinol it is not photolabile, so it can be used AM or PM, though daily sunscreen is still recommended. There is no oral, injectable, or systemic dose — it is not ingested. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical serum or cream (0.5-1% purified bakuchiol)

What you'll notice

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

💧 Reduced appearance of fine lines (small trials)positive

4-8 weeks

✅ Generally well tolerated on skinpositive

Throughout

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

💆 Reduced wrinkle appearance (comparable to retinol)positive

8-12 weeks

✅ Better tolerated than retinolpositive

Throughout

Safety

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to the peptide or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Other topical actives (retinoids, acids)
Injectable botulinum toxin (BoNT)

Side Effects:

Local skin irritation or rednessContact allergic reaction

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to bakuchiol or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Other leave-on actives (retinoids, acids)

Side Effects:

Mild local irritation or rednessContact allergic reaction

How they work together

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