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Topical cosmetic only. Argireline is typically formulated at 5-10% in leave-on serums, creams, or gels and applied to the target area (e.g., crow's-feet, forehead) twice daily. There is no oral, injectable, or systemic dose — it is not ingested. Concentration and formulation drive how much actually penetrates the skin. This library does not provide an ingestion protocol.

Any time

Leave-on topical cosmetic (serum, cream, or gel) at 5-10%

Topical cosmetic only. OTC retinol is formulated roughly 0.1-1% in leave-on serums or creams and applied to clean, dry facial skin at night, starting 2-3 nights per week and building to nightly as tolerated. There is no oral, injectable, or systemic dose — this is not ingested. Higher concentrations work somewhat better but irritate more; pair with a moisturizer and a morning sunscreen. This library does not provide an ingestion protocol.

Evening

Leave-on topical serum or cream (0.1-1% retinol)

• For topical (skin) use only — not for ingestion, not for injection
• Known allergy or sensitivity to the peptide or formulation excipients
• Application to broken, irritated, or compromised skin until healed

• Other topical actives (retinoids, acids)
• Injectable botulinum toxin (BoNT)

• For topical (skin) use only — not for ingestion, not for injection
• Pregnancy and breastfeeding — generally advised to avoid topical retinoids as a precaution
• Active eczema, rosacea flares, or broken/irritated/sunburned skin until healed

• Strong leave-on exfoliating actives (AHAs/BHAs, benzoyl peroxide)
• Other retinoids (prescription tretinoin, tazarotene, adapalene)