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Approved dosing is 150–250 mg once daily in the morning for narcolepsy and OSA, or 150 mg taken ~1 hour before the start of a night shift for shift-work disorder. A prescription drug; off-label cognitive use is not an approved or standardized regimen.

Morning

Oral tablet (armodafinil)

Approved dosing is 200 mg once daily in the morning for narcolepsy and OSA, or 200 mg taken ~1 hour before the start of a night shift for shift-work sleep disorder. A prescription drug; off-label cognitive use is not an approved or standardized regimen.

Morning

Oral tablet (modafinil)

• Prior hypersensitivity or serious skin reaction to armodafinil/modafinil
• History of left ventricular hypertrophy or mitral valve prolapse with prior stimulant use
• Uncontrolled hypertension or arrhythmia (use with caution)

• Hormonal contraceptives
• Warfarin / CYP2C19 substrates
• MAO inhibitors / other stimulants

• Prior hypersensitivity or serious skin reaction to modafinil/armodafinil
• History of left ventricular hypertrophy or mitral valve prolapse with prior stimulant use
• Uncontrolled hypertension or arrhythmia (use with caution)

• Hormonal contraceptives
• Warfarin / CYP2C19 substrates
• MAO inhibitors / other stimulants