Compare Supplements

Side-by-side comparison of 2 supplements

Ae7.0

Artichoke Extract

High safety

Tir7.8

Tirzepatide

Limited safety

Evidence

Evidence Score7/10

Studies: 39

Meta-analyses: 7

Evidence Score7.8/10

Studies: 13

Meta-analyses: 2

Dosage & timing

Dosage:

1200mg

Best Time:

With meals · with food

Can take on empty stomach

Form:

Standardized leaf extract (2.5-5% cynarin)

Dosage:

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

What you'll notice

👍 Improved Digestionpositive

2-4 weeks

❤️ Cholesterol Reductionpositive

8-12 weeks

💚 Liver Supportpositive

4-8 weeks

🩸 Strong glycemic controlpositive

Weeks to months

⚖️ Large weight losspositive

Months (dose-escalated over ~20 weeks)

😴 Reduced sleep-apnea severitypositive

Weeks to months

Safety

High safety

Contraindications:

Bile duct obstruction
Gallstones (use with caution)
Allergy to Asteraceae plants

Drug Interactions:

Blood pressure medications
Diabetes medications

Side Effects:

Increased gasAllergic reaction

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple endocrine neoplasia syndrome type 2 (MEN2)
History of pancreatitis (use with caution / avoid)

Drug Interactions:

Oral contraceptives
Insulin and sulfonylureas
Oral medications generally

Side Effects:

NauseaDiarrheaVomiting

Works well with

Milk Thistle

complementary

No synergies listed

How they work together

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