Artichoke Leaf Extract (Cynara scolymus)
Cynarin and chlorogenic acid stimulate bile production, support liver function, and modestly lower cholesterol levels.
Artichoke Leaf Extract has been used for centuries in Mediterranean traditional medicine for digestive and liver complaints. Modern research confirms its benefits for indigestion, stimulating bile production, supporting liver function, and modestly lowering cholesterol. The active compounds cynarin and chlorogenic acid provide its therapeutic effects.
Increases bile production and flow
Supports liver cell health and regeneration
Inhibits cholesterol synthesis
How Artichoke Extract works â from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta â pathways are being refined and expanded.
600-1200mg extract daily
Loading: Not required
Can be taken without food
| Form | Type |
|---|---|
| ðStandardized leaf extract (2.5-5% cynarin) | Recommended |
| ðCapsules | Alternative |
| ð§Liquid extract | Alternative |
Look for extracts standardized to cynarin or caffeoylquinic acid content.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Taking before meals, especially those containing fat, helps stimulate bile for better digestion.
Reduced bloating, nausea, and indigestion
Modest lowering of total and LDL cholesterol
Improved liver enzyme markers
Consult doctor - increased bile flow could be problematic
May decrease statin bioavailability; take 2+ hours apart
May affect blood clotting and increase bleeding risk
May enhance blood pressure-lowering effects
May enhance blood sugar lowering; monitor glucose
Tip: Start with lower dose
Tip: Avoid if allergic to daisies, ragweed, marigolds
Top studies from 38+ peer-reviewed papers
Sahebkar A et al. ⢠Critical reviews in food science and nutrition (2018)
âThus, supplementation with artichoke extract was associated with a significant reduction in both total and LDL-C, and triglycerides, suggesting that supplementation may be synergistic with lipid-lowering therapy in patients with hyperlipidemia.â
Porro C et al. ⢠Nutrients (2024)
âThe current review discussed the nutritional profiles, potential benefits, and pharmacological effects of C. scolymus.â
Derosa G et al. ⢠Phytotherapy research : PTR (2024)
âPhytotherapy Researchâ
Khaled A et al. ⢠Phytotherapy research : PTR (2023)
âMore clinical trials are required before new natural compounds and herbs can be used to treat chronic hypertension and its ramifications, such as respiratory distress syndrome and kidney failure.â
Salekzamani S et al. ⢠Phytotherapy research : PTR (2019)
âThis meta-analysis provided convincing evidence for antioxidant activity of artichoke in animals.â
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