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Artichoke Leaf Extract (Cynara scolymus)
Cynarin and chlorogenic acid stimulate bile production, support liver function, and modestly lower cholesterol levels.
What the evidence says
Artichoke Extract appears to help in 8 of 9 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2003–2025 with a typical study size of 90 participants.
Based on 37 studies · 8 meta-analyses · 13 RCTs · 2,485 total participants
Confidence
HighWhat the studies found
By outcome
See full supplement plans that include Artichoke Extract.
Artichoke Extract has an evidence score of 8.5/10 — very strong evidence based on 37 indexed studies, including 8 meta-analyses. Cynarin and chlorogenic acid stimulate bile production, support liver function, and modestly lower cholesterol levels.
The commonly studied dose of Artichoke Extract is 600-1200mg extract daily. Research points to an estimated optimal dose around 1200mg, with a minimum effective dose near 600mg. Individual response varies — start low and adjust.
The best time to take Artichoke Extract is with meals. Take it with food. Artichoke extract stimulates bile production (choleretic effect) and supports digestive enzyme function.
Last reviewed May 2026 · evidence from 38 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Artichoke Leaf Extract has been used for centuries in Mediterranean traditional medicine for digestive and liver complaints. Modern research confirms its benefits for indigestion, stimulating bile production, supporting liver function, and modestly lowering cholesterol. The active compounds cynarin and chlorogenic acid provide its therapeutic effects.
Increases bile production and flow
Supports liver cell health and regeneration
Inhibits cholesterol synthesis
How Artichoke Extract works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
600-1200mg extract daily
Loading: Not required
Can be taken without food
| Form | Type |
|---|---|
| 💊Standardized leaf extract (2.5-5% cynarin) | Recommended |
| 💊Capsules | Alternative |
| 💧Liquid extract | Alternative |
Look for extracts standardized to cynarin or caffeoylquinic acid content.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Taking before meals, especially those containing fat, helps stimulate bile for better digestion.
Based on meta-analysis of 702 subjects showing 17.6 mg/dL reduction in total cholesterol. Effect size is modest and may require 6+ weeks to manifest. Limited to artichoke leaf extract studies.
Reduced bloating, nausea, and indigestion
Modest lowering of total and LDL cholesterol
Improved liver enzyme markers
Consult doctor - increased bile flow could be problematic
May decrease statin bioavailability; take 2+ hours apart
May affect blood clotting and increase bleeding risk
May enhance blood pressure-lowering effects
May enhance blood sugar lowering; monitor glucose
Tip: Start with lower dose
Tip: Avoid if allergic to daisies, ragweed, marigolds
Artichoke Extract is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are increased gas, allergic reaction. Use caution if any of these apply to you: Bile duct obstruction; Gallstones (use with caution); Allergy to Asteraceae plants.
Inulin
Likely helpsPrebiotic fiber that selectively feeds Bifidobacteria and Lactobacilli, producing short-chain fatty acids for gut health and immunity.
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