Compare Supplements

Side-by-side comparison of 2 supplements

Asx5.0

Astaxanthin

High safety

Nia6.0

Niacinamide

High safety

Evidence

Evidence Score5/10

Studies: 70

Meta-analyses: 3

Evidence Score6/10

Studies: 7

Meta-analyses: 0

Outcome Grades

Skin hydration & glowC

Reduce wrinkles & fine linesD

Skin hydration & glowC

Reduce wrinkles & fine linesC

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

12mg

Best Time:

With meals · with food

Take with food

Form:

Softgels from Haematococcus pluvialis algae

Dosage:

Topical cosmetic only. Niacinamide is typically formulated at 2-5% in leave-on serums, creams, or gels and applied to clean skin once or twice daily (AM and/or PM). It layers well under sunscreen and with most other actives. There is no oral, injectable, or systemic dose in this cosmetic context — it is not ingested here. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical serum or cream (2-5% niacinamide)

What you'll notice

✨ Skin Healthpositive

6-12 weeks

👁️ Reduced Eye Fatigueneutral

4 weeks

💪 Lower Oxidative-Stress Markerspositive

2-4 weeks

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

🌗 Reduced hyperpigmentation / more even tonepositive

4-12 weeks

💧 Stronger barrier, less water loss, reduced sallownesspositive

2-12 weeks

Safety

High safety

Contraindications:

Allergy to algae or seafood (check source)

Drug Interactions:

Blood thinners

Side Effects:

Orange skin tint (very high doses)GI upset

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection (in this cosmetic context)
Known allergy or sensitivity to niacinamide or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Pure ascorbic acid (vitamin C) at low pH
Strong leave-on exfoliating actives (AHAs/BHAs, retinoids)

Side Effects:

Mild local irritation or rednessTransient flushing or tingling

Works well with

Omega-3

complementary

Vitamin C

complementary

Lutein + Zeaxanthin

complementary

No synergies listed

How they work together

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