Compare Supplements

Side-by-side comparison of 2 supplements

⚡

B-Complex

9/10high

🧬

Methylfolate

9/10high

Evidence

Evidence Score9/10

Studies: 40+

Meta-analyses: 20

Evidence Score9/10

Studies: 40+

Meta-analyses: 6

Dosage & Timing

Dosage:

1 capsule daily (per label)

Best Time:

Morning with breakfast

Take with food

Form:

Methylated B-complex (methylcobalamin, methylfolate)

Dosage:

400-800mcg daily

Best Time:

Morning with or without food, Consistent daily timing

Can take on empty stomach

Form:

L-Methylfolate (5-MTHF)

What You'll Notice

⚡ More Energy70%

2-4 weeks

😊 Better Mood60%

4-8 weeks

💛 Bright Yellow Urine95%

Immediate

😊 Improved Mood70%

2-4 weeks

⚡ Increased Energy65%

1-3 weeks

❤️ Lower Homocysteine80%

4-8 weeks

Safety

high safety rating

Contraindications:

Leber's disease (avoid high-dose B12)
Allergy to any B vitamin

Drug Interactions:

Levodopa
Methotrexate
Phenytoin

Side Effects:

NauseaBright yellow urineFlushing (high-dose niacin)

high safety rating

Contraindications:

History of bipolar disorder (may trigger mania - start very low)
Seizure disorders (high doses)

Drug Interactions:

Methotrexate
Anti-seizure medications

Side Effects:

Anxiety/irritabilityInsomniaHeadache

Works Well With

Magnesiumcomplementary

Omega-3stacks-well

5-HTPenhances

B-Complex (Methylated)complementary

L-Methionineenhances

Myo-Inositolcomplementary

How They Work Together

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Compare Supplements

B-Complex

Methylfolate

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

How They Work Together

Compare Supplements

B-Complex

Methylfolate

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

How They Work Together