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1-2 billion CFU (spores) daily. The IBS-D and gas/bloating trials used 2 x 10^9 CFU/day of MTCC 5856 (LactoSpore); the GBI-30 6086 (BC30) studies used 1 x 10^9 CFU/day.

Any time

Tablet or capsule delivering a named strain — MTCC 5856 (LactoSpore) for IBS, GBI-30 6086 (BC30) for the exercise and amino-acid claims

Prevention and maintenance are DIFFERENT doses and are often conflated. Preventing the first onset of acute pouchitis used 900 billion CFU/day (1 sachet). Maintaining remission in established chronic or refractory pouchitis — where the effect size is largest — used 6 g/day, which at 5 x 10^11 viable bacteria per gram is about 3 trillion CFU/day, in both maintenance trials. As a ulcerative colitis add-on, 3.6 trillion CFU daily; the active-UC induction trial went highest at 3.6 trillion CFU TWICE daily (7.2 trillion/day), and the paediatric trial lowest at 450 billion/day weight-based

Any time

Refrigerated sachet of the De Simone Formulation

• Immunocompromise or critical illness (a general precaution for live bacterial products; no trial enrolled such patients)

• Systemic antibiotics

• Severe immunocompromise or immunosuppression (class-level precaution for live probiotics)
• Critical illness or indwelling central venous catheter

• Systemic antibiotics