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Topical cosmetic only. Bakuchiol is typically formulated around 0.5-1% in leave-on serums or creams and applied to clean skin once or twice daily. Unlike retinol it is not photolabile, so it can be used AM or PM, though daily sunscreen is still recommended. There is no oral, injectable, or systemic dose — it is not ingested. This library does not provide an ingestion protocol.

Any time

Leave-on topical serum or cream (0.5-1% purified bakuchiol)

Topical cosmetic only. OTC retinol is formulated roughly 0.1-1% in leave-on serums or creams and applied to clean, dry facial skin at night, starting 2-3 nights per week and building to nightly as tolerated. There is no oral, injectable, or systemic dose — this is not ingested. Higher concentrations work somewhat better but irritate more; pair with a moisturizer and a morning sunscreen. This library does not provide an ingestion protocol.

Evening

Leave-on topical serum or cream (0.1-1% retinol)

• For topical (skin) use only — not for ingestion, not for injection
• Known allergy or sensitivity to bakuchiol or formulation excipients
• Application to broken, irritated, or compromised skin until healed

• Other leave-on actives (retinoids, acids)

• For topical (skin) use only — not for ingestion, not for injection
• Pregnancy and breastfeeding — generally advised to avoid topical retinoids as a precaution
• Active eczema, rosacea flares, or broken/irritated/sunburned skin until healed

• Strong leave-on exfoliating actives (AHAs/BHAs, benzoyl peroxide)
• Other retinoids (prescription tretinoin, tazarotene, adapalene)