Compare Supplements

180 mg orally once daily, with or without food, under a clinician. Available alone (Nexletol) or co-formulated with ezetimibe 10 mg (Nexlizet). A prescription drug — dosing is set by a prescriber.

Any time

Oral tablet (bempedoic acid 180 mg)

Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.

Morning

Oral tablet (canagliflozin)

• Concurrent simvastatin >20 mg or pravastatin >40 mg (bempedoic acid raises their levels)
• Active gout flare without management
• History of tendon rupture related to similar agents

• Simvastatin / pravastatin
• Corticosteroids / fluoroquinolones

• Type 1 diabetes (ketoacidosis risk)
• Severe renal impairment / dialysis
• History of recurrent diabetic ketoacidosis

• Diuretics
• Insulin / sulfonylureas